Dry powder aerosols to co-deliver antibiotics and nutrient dispersion compounds for enhanced bacterial biofilm eradication
| Autor: | L. Sanchez, Jennifer Fiegel, S. Sommerfeld Ross, Sachin Gharse |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Central composite design Chemistry Pharmaceutical Pharmaceutical Science Article 03 medical and health sciences 0302 clinical medicine Administration Inhalation Particle Size Ciprofloxacin Hydrochloride Aerosols Chromatography Inhalation Chemistry Biofilm Dry Powder Inhalers Anti-Bacterial Agents 030104 developmental biology 030228 respiratory system Biofilms Spray drying Yield (chemistry) Pseudomonas aeruginosa Particle Powders Dispersion (chemistry) |
| Zdroj: | International Journal of Pharmaceutics. 531:14-23 |
| ISSN: | 0378-5173 |
| Popis: | The purpose of this study was to formulate a dry powder for inhalation containing a combination treatment for eradication of Pseudomonas aeruginosa bacterial biofilms. Dry powders containing an antibiotic (ciprofloxacin hydrochloride, CH) and nutrient dispersion compound (glutamic acid, GA) at a ratio determined to eliminate the biofilms were generated by spray drying. Leucine was added to the spray dried formulation to aid powder flowability. A central composite design of experiments was performed to determine the effects of solution and processing parameters on powder yield and aerodynamic properties. Combinations of CH and GA eradicated bacterial biofilms at lower antibiotic concentrations compared to CH alone. Spray dried powders were produced with yields up to 43% and mass mean aerodynamic diameters (MMAD) in the respirable range. Powder yield was primarily affected by variables that determine cyclone efficiency, i.e. atomizer and solution flow rates and solution concentration; while MMAD was mainly determined by solution concentration. Fine particle fractions (FPF) |
| Databáze: | OpenAIRE |
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