CD4 T Cell-Dependent CD8 T Cell Maturation
| Autor: | Aaruni Khanolkar, Allan J. Zajac, Michael J. Fuller |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
CD4-Positive T-Lymphocytes
Cytotoxicity Immunologic Male Immunology Down-Regulation Epitopes T-Lymphocyte Priming (immunology) CD8-Positive T-Lymphocytes Lymphocytic Choriomeningitis Lymphocytic choriomeningitis Virus Mice Interleukin 21 T-Lymphocyte Subsets Lymphopenia medicine Animals Lymphocytic choriomeningitis virus Immunology and Allergy Cytotoxic T cell L-Selectin Mice Knockout CD40 biology CD44 CD28 Cell Differentiation medicine.disease Cell biology Mice Inbred C57BL Hyaluronan Receptors Acute Disease CD4 Antigens biology.protein Cytokines Female Immunologic Memory Cell Division |
| Zdroj: | The Journal of Immunology. 172:2834-2844 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | We have investigated the contribution of CD4 T cells to the optimal priming of functionally robust memory CD8 T cell subsets. Intranasal infection of CD4 T cell-deficient (CD4−/−) mice with lymphocytic choriomeningitis virus resulted in the elaboration of virus-specific CD8 T cell responses that cleared the infection. However, by comparison with normal mice, the virus-specific CD8 T cells in CD4−/− mice were quantitatively and qualitatively different. In normal mice, lymphocytic choriomeningitis virus-specific memory CD8 T cells are CD44high, many are CD122high, and a majority of these cells regain expression of CD62L overtime. These cells produce IFN-γ and TNF-α, and a subset also produces IL-2. In the absence of CD4 T cell help, a distinct subset of memory CD8 T cells develops that remains CD62Llow up to 1 year after infection and exhibits a CD44intCD122low phenotype. These cells are qualitatively different from their counterparts in normal hosts, as their capacity to produce TNF-α and IL-2 is diminished. In addition, although CD4-independent CD8 T cells can contain the infection following secondary viral challenge, their ability to expand is impaired. These findings suggest that CD4 T cell responses not only contribute to the optimal priming of CD8 T cells in chronically infected hosts, but are also critical for the phenotypic and functional maturation of CD8 T cell responses to Ags that are more rapidly cleared. Moreover, these data imply that the development of CD62Lhigh central memory CD8 T cells is arrested in the absence of CD4 T cell help. |
| Databáze: | OpenAIRE |
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