High tPA-expression in primary melanoma of the limb correlates with good prognosis
| Autor: | H. Schraffordt Koops, Dirk J. Ruiter, Huub Straatman, Ulrich R. Kleeberg, Ferdy Lejeune, Stefan Suciu, A. M. M. Eggermont, W. van Geloof, B. B. R. Kroon, C.M. Ferrier, G.N.P. van Muijen |
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| Přispěvatelé: | Surgery |
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Male
Cancer Research Pathology Skin Neoplasms Colorectal cancer MICROVASCULAR ENDOTHELIAL-CELLS Tissue plasminogen activator COLORECTAL-CANCER EPITHELIAL OVARIAN-CANCER PLASMINOGEN ACTIVATION SYSTEM Melanoma Adolescent Adult Aged Disease-Free Survival Extremities Female Follow-Up Studies Humans Immunohistochemistry Melanoma/chemistry Melanoma/pathology Middle Aged Neoplasm Invasiveness Neoplasm Staging Predictive Value of Tests Prognosis Sensitivity and Specificity Skin Neoplasms/chemistry Skin Neoplasms/pathology Tissue Plasminogen Activator/analysis Urokinase-Type Plasminogen Activator/analysis Regular Article Oncology Are components of the plasminogen activator system prognostic indicators in patients with cutaneous melanoma? Tissue Plasminogen Activator immunohistochemistry medicine.drug medicine.medical_specialty serine proteases TISSUE-TYPE Breslow Thickness Zijn componenten van het plasminogen activatiesysteem prognostische indicatoren bij patiënten met cutane melanomen? INHIBITOR TYPE-1 medicine melanoma tPA Klinische epidemiologie Urokinase business.industry Clinical epidemiology UROKINASE-TYPE Cancer IN-VITRO medicine.disease Urokinase-Type Plasminogen Activator NEGATIVE BREAST-CANCER Urokinase receptor pathology prognosis business GASTRIC-CANCER |
| Zdroj: | British Jounal of Cancer, 83(10), 1351-1359. Nature Publishing Group British Journal of Cancer British Journal of Cancer, 83, 1351-1359 British Journal of Cancer, 83, pp. 1351-1359 British Journal of Cancer, vol. 83, no. 10, pp. 1351-1359 British Journal of Cancer, 83(10), 1351-1359. Nature Publishing Group |
| ISSN: | 0007-0920 |
| Popis: | To investigate whether the course of primary melanoma disease correlates with expression of the various components of the proteolytic plasminogen activation (PA) system, immunohistochemical stainings for activators of plasminogen (tissue type (tPA) and urokinase type (uPA)), inhibitors of plasminogen activation (type 1 (PAI-I) and type 2 (PAI-2)) and the receptor for uPA (uPAR) were performed on 214 routinely processed melanoma lesions. All lesions were primary cutaneous melanomas, minimally 1.5 mm thick, and derived from patients with only local disease at the moment of diagnosis (clinically stage II (T3-4 NoMo), American Joint Committee on Cancer). Median patient follow-up was 6.1 years. Single variables as immunohistochemical staining results (extent of tumour cell staining, pattern of tumour cell staining and for some components also staining of stromal cells), histopathological and clinical parameters as well as treatment variables were analysed in order to assess their prognostic importance, in terms of time to recurrence, time to distant metastasis and duration of survival. The extent of tPA tumour cell positivity, categorized as 0-5%, 6-50% and 51-100%, appeared to be of importance for these endpoints. Lesions with 51-100% tPA-positive tumour cells were found to have the best prognosis, whereas lesions with 6-50% tPA-positive tumour cells had the worst. Moreover, the prognostic significance of Breslow thickness, microscopic ulceration and sex was confirmed in this study. Multivariate analyses, incorporating these relevant factors, showed that the extent of tPA tumour cell positivity was an independent prognostic factor for distant metastasis-free interval (P = 0.012) and for the duration of survival (P = 0.043). (C) 2000 Cancer Research Campaign. |
| Databáze: | OpenAIRE |
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