Metabolomics of prostate cancer: Knock-in versus knock-out prostate
| Autor: | Manoj Kumar, Ashish Gupta, Satya Narain Sankhwar, Anil Mandhani, Navneeta Bansal, Deepak Kumar, Hira Lal |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Oncology medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Glutamic Acid Pharmaceutical Science Analytical Chemistry Prostate cancer Metabolomics Prostate Internal medicine Gene knockin Drug Discovery Biomarkers Tumor medicine Humans Spectroscopy Chemistry Prostatectomy Glutamate receptor Prostatic Neoplasms medicine.disease medicine.anatomical_structure Biomarker (medicine) Gradual increase |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 205:114333 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/j.jpba.2021.114333 |
| Popis: | Several metabolomics-derived biomarkers of prostate cancer (PC) have been reported with pre-radical prostatectomy (RP) (knock-in PC) conditions; however, uncontested PC biomarkers panel appraisal and investigation of correlative evidence of these measures is lacking through post-RP (knock-out PC). We sought to explore patients’ filtered serum-based metabolomics derived signature measures in knock-in PC (n = 90) using nuclear magnetic resonance spectroscopy and multiple rigorous statistical analyses, and to develop the correlative evidence of these measures through knock-out PC (n = 90) follow-up on the 15th and 30th days. The glutamate, citrate and glycine were observed as hallmarks of PC. Observed trends revealed; augmented glutamate level in knock-in PC following a sudden drop and subsequently upside of glutamate at 15th and 30th days of knock-out PC, reduction of citrate in knock-in PC subsequently gradual increase of citrate in knock-out PC, and glycine lessening in knock-in PC following augmentation on 30th day of knock-out PC. This study-based evidence clears the doubts regarding the discovery of metabolomics-derived PC biomarkers. |
| Databáze: | OpenAIRE |
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