To switch or not to switch: Intentions to switch to injectable PrEP among gay and bisexual men with at least twelve months oral PrEP experience

Autor: Atrina L. Brill, Sarit A. Golub, Kathrine Meyers, Theodorus G. M. Sandfort, Yumeng Wu
Rok vydání: 2018
Předmět:
Male
Physiology
Emotions
Sensory Physiology
Administration
Oral
Social Sciences
lcsh:Medicine
HIV Infections
Intention
Surveys
Sexual and Gender Minorities
Pre-exposure prophylaxis
Cognition
0302 clinical medicine
Medicine and Health Sciences
Psychology
Ethnicities
030212 general & internal medicine
Homosexuality
Young adult
lcsh:Science
Hispanic People
media_common
Multidisciplinary
Drug Substitution
Middle Aged
Sensory Systems
3. Good health
Somatosensory System
Research Design
Pill
Engineering and Technology
0305 other medical science
Management Engineering
Psychosocial
Research Article
Adult
medicine.medical_specialty
Anti-HIV Agents
media_common.quotation_subject
Decision Making
HIV prevention
MEDLINE
Research and Analysis Methods
Injections
Intramuscular
Young Adult
Insurance
03 medical and health sciences
medicine
Humans
Homosexuality
Male
Preventive medicine
Psychological and Psychosocial Issues
Risk Management
Survey Research
030505 public health
Modalities
lcsh:R
Cognitive Psychology
Biology and Life Sciences
Pain Sensation
Health Care
Public and occupational health
Delayed-Action Preparations
Family medicine
People and Places
Cognitive Science
Pre-Exposure Prophylaxis
Population Groupings
lcsh:Q
Neuroscience
Patient education
Zdroj: PLoS ONE, Vol 13, Iss 7, p e0200296 (2018)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0200296
Popis: Background Phase III trials of long-acting injectable (LAI) PrEP, currently underway, have great potential for expanding the menu of HIV prevention options. Imagining a future in which multiple PrEP modalities are available to potential users of biomedical HIV prevention, we investigated which factors might help direct a patient-physician shared-decision making process to optimize the choice of biomedical HIV prevention method. Methods Participants (n = 105; ages 19-63; 46.7% men of color) were former participants in a PrEP demonstration project and had taken daily oral PrEP for ≥ 12 months. Participants were given information about LAI PrEP and asked whether they would be interested in switching from oral to LAI PrEP. Participants were also asked about specific pros/cons of LAI PrEP, PrEP attitudes and experiences, and personality factors. Results Two-thirds (66.7%) of current oral PrEP users would switch to LAI PrEP. Intention to switch was associated with product-level and psychosocial factors. Attitudes towards logistical factors (i.e. getting to regular clinic visits for recurring shots) featured more prominently than factors related to the physical experience of PrEP modality (i.e., concerns about injection pain) as motivators for switching. In a multivariate regression model, psychosocial factors including the emotional burden of daily pill taking, deriving a sense of responsibility from PrEP use, and self-identifying as an early adopter, were the strongest predictors of switching. Conclusions These data underscore the importance of attending not only to product-level factors, but also to the logistical and psychological experience of prevention methods for users. Findings have significant implications for the development of patient education materials and patient-provider shared decision aids.
Databáze: OpenAIRE
Externí odkaz: