Increased quinolinate immunoreactivity in the peripheral blood monocytes/macrophages from SIV-infected monkeys
| Autor: | D. Carleton Gajdusek, Clarence J. Gibbs, John R. Moffett, Chettemgere N S Venkateshan, Maneth Gravell, Rekha Narayanan, Aryan M A Namboodiri, Karen Blinder |
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| Rok vydání: | 1996 |
| Předmět: |
Pathology
medicine.medical_specialty Kynurenine pathway Excitotoxicity Simian Acquired Immunodeficiency Syndrome Biology medicine.disease_cause Monocytes Cellular and Molecular Neuroscience chemistry.chemical_compound Antibody Specificity Virology medicine Neurotoxin Animals Receptor Cells Cultured Kynurenine Cell Size Macrophages Tryptophan Quinolinic Acid Molecular biology Quinolinate Immunohistochemistry Macaca mulatta Neurology chemistry Giant cell Simian Immunodeficiency Virus Neurology (clinical) Quinolinic acid |
| Zdroj: | Journal of neurovirology. 2(6) |
| ISSN: | 1355-0284 |
| Popis: | Quinolinate (QUIN), a metabolite in the kynurenine pathway of tryptophan degradation and a neurotoxin that is thought to act through the NMD A receptor system, was localized in cultured peripheral blood monocytes/macrophages from SIV-infected monkeys using a recently developed imrnunohistochemical method. Significant increases in QUIN immunoreactive (IR) cells were detected in all five SIV-infected monkeys examined. Multinucleated giant cells, a hallmark of lentiviral infection, were visible in selected samples. Treatment with the QUIN precursors, tryptophan and kynurenine, increased the number of QUIN-IR cells in both the control and SIV-infected preparations, perhaps by a mass action mechanism. We hypothesize that in SIV-infected monkeys, infiltrating monocytes/macrophages contribute to the high level of brain QUIN and associated neuropathology. |
| Databáze: | OpenAIRE |
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