Correlation of Vascular and Inflammatory Index in Oral Pyogenic Granuloma and Periapical Granuloma - An Insight into Pathogenesis
| Autor: | Anuradha Ananthaneni, Joy Thomas Vara, Bhavana S Bagalad, Puneeth Horatti Kuberappa, Hari Priya Ponnapalli, Vijay Srinivas Gurudu |
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| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Angiogenesis medicine.medical_treatment Clinical Biochemistry lcsh:Medicine Periapical Granuloma Inflammation vegf-r Pathogenesis angiogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Pathological vegf angiostatin business.industry Pyogenic granuloma lcsh:R 030206 dentistry General Medicine medicine.disease Dentistry Section Vascular endothelial growth factor Cytokine chemistry inflammation 030220 oncology & carcinogenesis medicine.symptom business |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 11, Iss 5, Pp ZC25-ZC28 (2017) |
| ISSN: | 2249-782X |
| Popis: | Introduction Angiogenesis is vital in the aetiology and pathogenesis of a number of pathological processes that include solid reactive lesions like pyogenic granuloma and chronic inflammatory disorders like periapical granuloma. Vascular Endothelial Growth Factor (VEGF) is a potent proangiogenic cytokine secreted by many cell types which present several pivotal functions in physiologic and pathologic angiogenesis. Aim The aim of the present study was to evaluate and compare the expression of VEGF in oral Pyogenic Granuloma (PG) and Periapical Granuloma (PAG) and also to correlate with the inflammatory cell infiltrate. Materials and methods Paraffin embedded tissue blocks of histologically diagnosed cases of PG and PAG, 20 of each were retrieved from the archives. The cases were selected randomly to evaluate the expression of VEGF marker and to assess the Mean Vascular Count (MVC) index and inflammation by Morphological Index (MI). The results were analysed using Unpaired t-test, Mann-Whitney U test and spearman correlation coefficient-test. Results The PG showed higher expression of VEGF when compared to PAG with no significant difference in inflammation. PG showed positive correlation and PAG showed negative correlation between inflammation and VEGF expression. Conclusion Histologically similar PG and PAG are different not only by their clinical presentation but also by their mechanisms of formation and molecular sketch. Thereby raised expression of VEGF marker was established in PG emphasizing the fact that all histologically similar lesions need not have similar clinical course and molecular depiction. |
| Databáze: | OpenAIRE |
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