Effects of Single and Repeated Oral Doses of Ochratoxin A on the Lipid Peroxidation and Antioxidant Defense Systems in Mouse Kidneys
| Autor: | Miklós Mézes, Zsuzsanna Szőke, Sándor Szoboszlay, Krisztián Balogh, Csilla Krifaton, Mihály Albert, Szilamér Ferenczi, Mátyás Cserháti, József Kukolya, Balázs Kriszt, Krisztina J. Kovács, Dániel Kuti |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Ochratoxin A
Male kidney Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment lcsh:Medicine Pharmacology Toxicology medicine.disease_cause Article Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Blood plasma Medicine Animals oxidative stress glutathione Carcinogen 030304 developmental biology 0303 health sciences Kidney Kelch-Like ECH-Associated Protein 1 business.industry lcsh:R ochratoxin-A Glutathione Ochratoxins medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis gene expression Lipid Peroxidation business Oxidoreductases Oxidative stress |
| Zdroj: | Toxins Volume 12 Issue 11 Toxins, Vol 12, Iss 732, p 732 (2020) |
| ISSN: | 2072-6651 |
| Popis: | Ochratoxin-A (OTA) is a carcinogenic and nephrotoxic mycotoxin, which may cause health problems in humans and animals, and it is a contaminant in foods and feeds. The purpose of the present study is to evaluate the effect of oral OTA exposure on the antioxidant defense and lipid peroxidation in the kidney. In vivo administration of OTA in CD1, male mice (1 or 10 mg/kg body weight in a single oral dose for 24 h and repeated daily oral dose for 72 h or repeated daily oral dose of 0.5 mg/kg bodyweight for 21 days) resulted in a significant elevation of OTA levels in blood plasma. Some histopathological alterations, transcriptional changes in the glutathione system, and oxidative stress response-related genes were also found. In the renal cortex, the activity of the glutathione-system-related enzymes and certain metabolites of the lipid peroxidation (conjugated dienes, trienes, and thiobarbituric reactive substances) also changed. |
| Databáze: | OpenAIRE |
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