The effect of intravenous lidocaine infusion on bispectral index during major abdominal surgery
| Autor: | J. Stevens, James R. Padley, Matthew Ho, Erez Ben-Menachem, Patrick Bazin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Minimum alveolar concentration medicine.medical_specialty Lidocaine medicine.drug_class Health Informatics Anesthesia General Critical Care and Intensive Care Medicine Fentanyl 03 medical and health sciences 0302 clinical medicine Bolus (medicine) 030202 anesthesiology Heart Rate Anesthesiology Monitoring Intraoperative Abdomen medicine Humans Infusions Intravenous Aged Anesthetics Laparotomy Local anesthetic business.industry Electroencephalography Middle Aged Surgery Anesthesiology and Pain Medicine Anesthesia Bispectral index Surgical Procedures Operative Anesthetic Female business Colorectal Neoplasms 030217 neurology & neurosurgery Anesthetics Intravenous medicine.drug |
| Zdroj: | Journal of clinical monitoring and computing. 32(3) |
| ISSN: | 1573-2614 |
| Popis: | Intraoperative lidocaine infusion has become widely accepted as an adjunct to general anesthesia where its use has been associated with opioid-sparing and enhanced recovery. The aims of this study were to determine whether or not intravenous (IV) lidocaine infusion (a) has an anesthetic sparing effect during major colorectal procedures and (b) if it also affects level of hypnosis as measured by bispectral index (BIS). Twenty-five patients undergoing laparotomy for resection of colorectal tumours were randomized to receive either IV lidocaine (1.5 mg kg−1 bolus then 1 mg kg−1 per hour) or an equivalent volume of normal saline commenced after intravenous induction of general anesthesia. Anesthesia was maintained with volatile anesthetic agent combined with intermittent IV fentanyl titrated to hemodynamic stability. Minimum alveolar concentration (MAC) of volatile was calculated using an age-adjusted algorithm (corrected MAC). BIS values were recorded throughout; however, treating anesthesiologists were blinded to BIS values and hence they were not used to guide depth of anesthesia. No other regional anesthesia techniques were used. During the maintenance phase of anesthesia, corrected MAC of volatile agent was lower (1.0 versus 1.1, p = 0.003); whereas BIS values were higher (45 versus 39, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink