Identification of fatty acid binding proteins as markers associated with the initiation and/or progression of renal cell carcinoma
| Autor: | Barbara Malenica, Barbara Seliger, Alois Harder, Monica Zobawa, Walburgis Brenner, Friedrich Lottspeich, Angelika Ackermann, Jürgen Bukur, Michael Kersten, Thomas M. Halder, Rudolf Lichtenfels, Derek Atkins |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Disease
Biology Fatty Acid-Binding Proteins Kidney urologic and male genital diseases medicine.disease_cause Biochemistry Metastasis Reference Values Renal cell carcinoma Cell Line Tumor Biomarkers Tumor medicine Carcinoma Humans Electrophoresis Gel Two-Dimensional Urothelium Carcinoma Renal Cell neoplasms Molecular Biology DNA Primers Reverse Transcriptase Polymerase Chain Reaction Prognosis medicine.disease Immunohistochemistry Kidney Neoplasms female genital diseases and pregnancy complications Gene Expression Regulation Neoplastic medicine.anatomical_structure Immunology Disease Progression Cancer research Carrier Proteins Carcinogenesis Kidney disease |
| Zdroj: | PROTEOMICS. 5:2631-2640 |
| ISSN: | 1615-9861 1615-9853 |
| DOI: | 10.1002/pmic.200401264 |
| Popis: | Renal cell carcinoma (RCC) representing the most common neoplasia of the kidney in Western countries is a histologic diverse disease with an often unpredictable course. The prognosis of RCC is worsened with the onset of metastasis, and the therapies currently available are of limited success for the treatment of metastatic RCC. Although gene expression analyses and other methods are promising tools clarifying and standardizing the pathological classification of RCC, novel innovative molecular markers for the diagnosis, prognosis, and for the monitoring of this disease during therapy as well as potential therapeutic targets are urgently needed. Using proteome-based strategies, a number of RCC-associated markers either over-expressed or down-regulated in tumor lesions in comparison to the normal epithelium have been identified which have been implicated in tumorigenesis, but never linked to the initiation and/or progression of RCC. These include members of the fatty acid binding protein family, which have the potential to serve as diagnostic or prognostic markers for the screening of RCC patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text