Antipyrene clearance in Indian villagers
| Autor: | SW Jones, UK Sheth, JC Mucklow, NK Desai, HS Fraser, Colin T. Dollery, Christopher J. Bulpitt |
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| Rok vydání: | 1980 |
| Předmět: |
Adult
Male Saliva medicine.medical_specialty India Physiology medicine.disease_cause Hemoglobins Sex Factors Sex factors Internal medicine Infestation medicine Humans Pharmacology (medical) Pharmacology Volume of distribution business.industry Middle Aged Diet Endocrinology Female Negative correlation ANTIPYRINE METABOLISM business Antipyrine Research Article Half-Life |
| Zdroj: | British Journal of Clinical Pharmacology. 9:387-394 |
| ISSN: | 0306-5251 |
| Popis: | 1 Antipyrine clearance has been measured using saliva samples in 50 Maharashtrans from a village to the north of Bombay. 2 All subjects were very lean and were also anaemic probably as a result of hookworm infestation. 3 Antipyrine clearance was 36% faster than in White Londoners studied previously and more than twice as fast as in Asian immigrants living in London. 4 Clearance was 25% faster in men than in women but volume of distribution was also greater in men and mean half-lives did not differ significantly between the sexes. 5 There was a negative correlation between antipyrine clearance and haemoglobin concentration. 6 The study has identified geographic differences in antipyrine metabolism which could be clinically important. The role of anaemia merits further study. |
| Databáze: | OpenAIRE |
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