Enhanced Neuronal Activation with Blueberry Supplementation in Mild Cognitive Impairment
| Autor: | Amanda N. Stover, Wilhelmina Kalt, Robert Krikorian, Erin L. Boespflug, James C. Eliassen, Jonathan Dudley, Suzanne S. Summer, Amanda L. Stein, Marcelle D. Shidler |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Brain activation Male Blueberry Plants Medicine (miscellaneous) Physiology Prefrontal Cortex Article Anthocyanins 03 medical and health sciences 0302 clinical medicine Gyrus Double-Blind Method Parietal Lobe medicine Dementia Humans Cognitive Dysfunction Effects of sleep deprivation on cognitive performance Cognitive impairment Aged Aged 80 and over Nutrition and Dietetics medicine.diagnostic_test Working memory General Neuroscience Brain Cognition General Medicine medicine.disease Magnetic Resonance Imaging Frontal Lobe 030104 developmental biology medicine.anatomical_structure Memory Short-Term Fruit Dietary Supplements Female Psychology Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery |
| Popis: | Preclinical studies have shown that blueberry supplementation can improve cognitive performance and neural function in aged animals and have identified associations between anthocyanins and such benefits. Preliminary human trials also suggest cognitive improvement in older adults, although direct evidence of enhancement of brain function has not been demonstrated. In this study, we investigated the effect of blueberry supplementation on regional brain activation in older adults at risk for dementia.In a randomized, double-blind, placebo-controlled trial we performed pre- and post-intervention functional magnetic resonance imaging during a working memory (WM) task to assess the effect of blueberry supplementation on blood oxygen level-dependent (BOLD) signal in older adults with mild cognitive impairment, a risk condition for dementia.Following daily supplementation for 16 weeks, blueberry-treated participants exhibited increased BOLD activation in the left pre-central gyrus, left middle frontal gyrus, and left inferior parietal lobe during WM load conditions (corrected P 0.01). There was no clear indication of WM enhancement associated with blueberry supplementation. Diet records indicated no between-group difference in anthocyanin consumption external to the intervention.These data demonstrate, for the first time, enhanced neural response during WM challenge in blueberry-treated older adults with cognitive decline and are consistent with prior trials showing neurocognitive benefit with blueberry supplementation in this at-risk population. |
| Databáze: | OpenAIRE |
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