Follistatin decreases activin-stimulated FSH secretion with no effect on GnRH-stimulated FSH secretion in prepubertal male monkeys
| Autor: | J P Mather, M C Meriggiola, K D Dahl, W J Bremner |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Follistatin endocrine system Pituitary gland medicine.medical_specialty medicine.drug_class Endogeny Gonadotropin-Releasing Hormone Endocrinology In vivo Internal medicine medicine Animals Inhibins Sexual Maturation Testosterone Glycoproteins Dose-Response Relationship Drug biology Chemistry In vitro Activins Macaca fascicularis medicine.anatomical_structure embryonic structures biology.protein Follicle Stimulating Hormone Gonadotropin Spermatogenesis hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrinology. 134:1967-1970 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo.134.4.8137764 |
| Popis: | Follistatin is an activin-binding glycoprotein that decreases FSH secretion in vitro and in vivo in rats. The mechanism by which follistatin acts is unclear, but it has been suggested that it may bind endogenous activin and neutralize its effects. In this study, we wished to test the ability of follistatin to suppress FSH secretion in vivo in primates whose FSH secretion has been stimulated by activin or by GnRH. Six prepubertal male monkeys were injected intravenously with human recombinant follistatin at the dose of 90 micrograms/kg or 180 micrograms/kg plus activin (90 micrograms/kg) or GnRH (10 micrograms/kg). Frequent blood samples were drawn for 12 hours following each injection. Bio FSH and LH levels were measured in those samples. GnRH and activin each stimulated FSH bioactivity. Both doses of follistatin significantly inhibited the activin-induced increase in FSH (p0.05). The GnRH-induced increase in FSH was not affected by follistatin. LH levels were not affected by follistatin in any of the studies. These data suggest that follistatin can suppress the activin-induced increase in FSH in primates and is consistent with the hypothesis that follistatin can block the physiological effects of endogenous activin in primates. This effect is likely to be due to the binding of follistatin to activin either in the peripheral circulation or at the pituitary level. |
| Databáze: | OpenAIRE |
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