Predictors of quality of life among adolescents and young adults with a bleeding disorder
Autor: | James Munn, Michelle Witkop, Bartholomew J Tortella, John M McLaughlin, Terry L. Anderson, Angela Lambing |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Cross-sectional study Patient adherence Severe disease Chronic pain 030204 cardiovascular system & hematology Hemophilia A lcsh:Computer applications to medicine. Medical informatics Severity of Illness Index 03 medical and health sciences Young Adult 0302 clinical medicine Quality of life Surveys and Questionnaires Severity of illness Von Willebrand disease medicine Health Status Indicators Humans Young adult Hemophilia Clotting factor business.industry Prophylaxis Research Public Health Environmental and Occupational Health Reproducibility of Results General Medicine medicine.disease humanities Pain management Cross-Sectional Studies Quality of Life lcsh:R858-859.7 Female business von Willebrand disease 030215 immunology |
Zdroj: | Health and Quality of Life Outcomes, Vol 15, Iss 1, Pp 1-9 (2017) Health and Quality of Life Outcomes |
ISSN: | 1477-7525 |
Popis: | Background Health-related quality of life (HRQoL) in adolescents and young adults with bleeding disorders is under-researched. We aimed to describe factors related to HRQoL in adolescents and young adults with hemophilia A or B or von Willebrand disease. Methods A convenience sample of volunteers aged 13 to 25 years with hemophilia or von Willebrand disease completed a cross-sectional survey that assessed Physical (PCS) and Mental (MCS) Component Summary scores on the SF-36 questionnaire. Quantile regression models were used to assess factors associated with HRQoL. Results Of 108 respondents, 79, 7, and 14% had hemophilia A, hemophilia B, and von Willebrand disease, respectively. Most had severe disease (71%), had never developed an inhibitor (65%), and were treated prophylactically (68%). Half of patients were aged 13 to 17 years and most were white (80%) and non-Hispanic (89%). Chronic pain was reported as moderate to severe by 31% of respondents. Median PCS and MCS were 81.3 and 75.5, respectively. Quantile regression showed that the median PCS for women (61% with von Willebrand disease) was 13.1 (95% CI: 2.4, 23.8; p = 0.02) points lower than men. Ever developing an inhibitor (vs never) was associated with a 13.1-point (95% CI: 4.7, 21.5; p |
Databáze: | OpenAIRE |
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