Line‐field confocal optical coherence tomography of xanthogranuloma: Correlation with vertical and horizontal histopathology

Autor:	Giuseppe Broggi, Davide Francesco Puglisi, Rosario Caltabiano, Francesco Lacarrubba, Giuseppe Micali, Anna Elisa Verzì
Rok vydání:	2021
Předmět:	Pathology medicine.medical_specialty Histology Materials science line-field confocal optical coherence tomography genetic structures Confocal Case Report Case Reports Dermatology Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Touton giant cell xanthogranuloma medicine foamy histiocytes medicine.diagnostic_test line‐field confocal optical coherence tomography Papule eye diseases Line field Dermal papillae medicine.anatomical_structure Giant cell Touton cells 030220 oncology & carcinogenesis histopathology Histopathology sense organs medicine.symptom
Zdroj:	Journal of Cutaneous Pathology
ISSN:	1600-0560 0303-6987
DOI:	10.1111/cup.14067
Popis:	Line‐field confocal optical coherence tomography (LC‐OCT) is a new noninvasive technique for a real‐time, vertical, and horizontal imaging of the skin at cellular resolution. A 47‐year‐old female presented with a 6‐month history of an asymptomatic yellowish papule. LC‐OCT evaluation was able to show the diagnostic microscopic features of xanthogranuloma and showed an excellent correlation with vertical and horizontal histopathological sections by revealing enlarged dermal papillae containing multiple, bright roundish giant cells, corresponding to foamy histiocytes, and giant cells characterized by a dark center surrounded by a highly hyper‐refractile peripheral ring, corresponding to Touton cells. LC‐OCT may represent a valid, noninvasive alternative to histopathological examination in clinically atypical cases of xanthogranuloma.
Databáze:	OpenAIRE
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