Antioxidant supplementation, redox deficiencies and exercise performance: A falsification design
| Autor: | Nikos V. Margaritelis, Antonios Kyparos, Michalis G. Nikolaidis, Vassilis Paschalis, Anastasios A. Theodorou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antioxidant medicine.medical_treatment Urine Ascorbic Acid medicine.disease_cause Biochemistry Redox Antioxidants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physiology (medical) Internal medicine Exercise performance medicine Humans Vitamin E F2-Isoprostanes Cross-Over Studies Vitamin C business.industry Glutathione Crossover study Oxidative Stress 030104 developmental biology Endocrinology chemistry Dietary Supplements business Oxidation-Reduction 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Free radical biologymedicine. 158 |
| ISSN: | 1873-4596 |
| Popis: | The aim of the present study was to validate the idea of personalized redox supplementation by subjecting individuals to targeted and non-targeted antioxidant supplementation schemes. Seventy-three volunteers were screened for plasma vitamin C and erythrocyte glutathione levels. Three groups were formed: i) the “low vitamin C″ group (12 individuals with the lowest vitamin C levels; Low VitC), ii) the “low glutathione” group (12 individuals with the lowest glutathione levels; Low GSH) and iii) a control group (12 individuals with moderate vitamin C and glutathione levels). The three groups received 1 g of vitamin C or 1.2 g of NAC daily for 30 days in a crossover design with a wash-out period of 30 days. Both antioxidant treatments reduced the increased resting systemic oxidative stress levels, assessed via urine F2-isoprostanes, in the Low VitC and Low GSH groups (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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