VOLTAMMETRIC AND CHROMATOGRAPHIC DETERMINATION OF NAPROXEN IN DRUG FORMULATION
| Autor: | Ozlem Tonguc Yayintas, Gulsen Saglikoglu, Murat Sadikoglu, Selehattin Yilmaz, Suzan Yanik |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Detection limit
Naproxen Chromatography Fen Chemistry musculoskeletal neural and ocular physiology Science fungi commercial drug tablets. naproxen voltammetric method differential pulse voltammetry cyclic voltammetry high performance liquid chromatography ultra-trace graphite electrode Electrolyte Pharmaceutical formulation High-performance liquid chromatography Nap naproxen voltammetric method differential pulse voltammetry cyclic voltammetry high performance liquid chromatography ultra-trace graphite electrode commercial drug tablets mental disorders medicine Differential pulse voltammetry Cyclic voltammetry human activities psychological phenomena and processes medicine.drug |
| Zdroj: | Volume: 3, Issue: 4 299-310 Journal of Scientific Perspectives |
| ISSN: | 2587-3008 |
| Popis: | In this work, the electrochemical oxidation of naproxen (NAP) was studied at an ultra-trace graphite electrode (UTGE). The cyclic voltammetry (CV) technique was used to determine the optimum conditions and the effect of pH on the electrochemical oxidation of NAP. Acetate buffer (pH 4.50) was selected as the support electrolyte due to obtaining the highest electronic signal increase during oxidation of NAP at UTGE. The differential pulse voltammetry (DPV) technique was performed for electrochemical determination of NAP. In the optimum conditions, the limits of detection (LOD) and quantification (LOQ) were determined to be 8.6610-8 M and 2.8810-7 M. In addition, the amount of NAP was determined in drug tablets. The recovery studies of NAP from the drug tablet were completed in order to check the accuracy and precision of the applied voltammetric method. Furthermore, the determination of NAP was performed with the high-performance liquid chromatography (HPLC) method. These two methods were compared in terms of accuracy, precision and recovery studies. |
| Databáze: | OpenAIRE |
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