Presence of CXCR4-Using HIV-1 in Patients With Recently Diagnosed Infection: Correlates and Evidence for Transmission
| Autor: | Jean Plum, Kristen Chalmet, Chris Verhofstede, Beatrijs Van Der Gucht, Kenny Dauwe, Franky Baatz, Lander Foquet, Dirk Vogelaers, Carole Seguin-Devaux, Linos Vandekerckhove |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Receptors CXCR4 medicine.medical_specialty Genotype Receptors CCR5 T cell HIV Infections Drug resistance HIV Envelope Protein gp120 Biology CXCR4 Statistics Nonparametric law.invention Evolution Molecular law Epidemiology medicine Cluster Analysis Humans Immunology and Allergy Sequence Analysis RNA Virology Peptide Fragments Reverse transcriptase CD4 Lymphocyte Count Viral Tropism Infectious Diseases medicine.anatomical_structure Transmission (mechanics) Immunology HIV-1 RNA Viral Female Viral load |
| Zdroj: | The Journal of Infectious Diseases. 205:174-184 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jir714 |
| Popis: | Background. The prevalence and correlates of CXCR4-use in recently diagnosed patients and the impact of X4/DM transmission remain largely unknown. Method. Genotypic coreceptor use determination on the baseline sample of 539 recently diagnosed individuals. Correlation of coreceptor use with clinical, viral and epidemiological data and with information on transmission events as obtained through phylogenetic analysis of protease and reverse transcriptase sequences. Results. CXCR4-use was predicted in 12 to 19% of the patients, depending on the interpretative cutoff used. CXCR4-use was correlated with lower CD4(+) T cell counts and subtype 01_AE infection. No association with viral load was observed. Seven (11%) of 63 transmission clusters and 4 (31%) of 13 donor-source pairs resulted from X4/DM transmission. Conclusion. The results confirmed the relation between CXCR4-use at diagnosis and low baseline CD4+ T cell counts. Significantly more CXCR4-use was predicted in 01_AE infections, which may impose constraints on the use of CCR5 antagonists in certain regions of the world. Observations from the transmission cluster analysis contradict the hypothesis that R5 viruses are selected at transmission, and support the idea that R5 or X4/DM infections result from a stochastic process. |
| Databáze: | OpenAIRE |
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