Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva
| Autor: | Roger Hall, Vishvanath Nene, Elizabeth Glass, Subhash Morzaria, Nicola Boulter, E. Kirvar, Antony Musoke, Gwen Wilkie, C.G.D. Brown |
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| Rok vydání: | 2000 |
| Předmět: |
Protozoan Vaccines
Theileria parva Reciprocal cross Immunology Protozoan Proteins Antibodies Protozoan Antigens Protozoan law.invention Antigen law parasitic diseases Homologous chromosome Animals Parasite hosting Immunization Schedule biology biology.organism_classification Theileria annulata Virology Recombinant Proteins Theileriasis Immunization Recombinant DNA biology.protein Cattle Parasitology Antibody |
| Zdroj: | Parasite Immunology. 22:223-230 |
| ISSN: | 1365-3024 0141-9838 |
| Popis: | Theileria annulata and Theileria parva both possess a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These antigens share sequence homology and are serologically cross-reactive. Here, we confirm that these antigens confer protection against homologous species challenge. More importantly, they mutually confer a degree of cross-species protection raising the prospect of a common vaccine in the future. |
| Databáze: | OpenAIRE |
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