Treatment of anti-recombinant interferon-alpha 2 antibody positive CML patients with natural interferon-alpha
| Autor: | F. Brockhaus, Jakschies D, Mathias Freund, Peter von Wussow, Ruediger Hehlmann, Heinz-Kurt Hochkeppel, Helmuth Deicher, Horisberger M |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Antibodies Neoplasm medicine.medical_treatment Alpha (ethology) Alpha interferon Biology Interferon alpha-2 Antiviral Agents Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans Neutralizing antibody Interferon alfa Interferon-alpha Hematology Immunotherapy Blood Proteins Recombinant Proteins Titer Cytokine Immunology Interferon Type I biology.protein Female Antibody medicine.drug |
| Zdroj: | British journal of haematology. 78(2) |
| ISSN: | 0007-1048 |
| Popis: | Of 38 patients with a Philadelphia-chromosome positive chronic myeloid leukaemia treated with recombinant interferon alpha (rIFN-alpha) 2a or 2b and monitored for emergence of IFN-antibodies in their sera 11 patients developed rIFN-alpha 2 binding and 10 rIFN-alpha 2 neutralizing antibodies. rIFN-alpha neutralizing antibody positive patients experienced significantly (P less than 0.025) more clinical relapses (6/10) than IFN-antibody negative patients (6/28) during continuous IFN-therapy. Furthermore, IFN-antibody-positive patients with titre above 400 INU/ml were more likely to relapse under rIFN-alpha-therapy than IFN-antibody-negative patients with titre below 400 INU/ml (P less than 0.05). Seven rIFN-antibody-positive patients experiencing a clinical relapse or a primary non-responsiveness were treated with two- to three-fold increased doses of rIFN-alpha 2. Only one of these seven patients developed a partial haematological remission upon intensification of the rIFN-alpha 2 therapy. Consecutively, the six patients failing high dose rIFN-alpha treatment were switched to a natural IFN-alpha preparation (3 x 9 x 10(6) I.U. weekly s.c.). Under such treatment two of the six patients achieved a long-lasting complete, one a partial haematological remission. In high-titred IFN-antibody positive patients significantly altered serum-IFN-titre and minimal IFN-inducible Mx-homologue concentrations were measured; in contrast, nIFN-alpha induced normal IFN-titre and dose-equivalent Mx-homologue amounts in these patients. The data prove that high-titred rIFN-alpha neutralizing antibodies abrogate the biological action of rIFN-alpha, but not of nIFN-alpha in vivo and explains why nIFN-alpha can be effective in the anti rIFN-alpha 2 positive patients. |
| Databáze: | OpenAIRE |
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