Regional brain tissue integrity in pediatric obstructive sleep apnea

Autor: David Gozal, Paul M. Macey, Ashish Sahib, Mona F. Philby, Leila Kheirandish-Gozal, Rajesh Kumar
Rok vydání: 2018
Předmět:
Male
Entropy
Insula
Brain tissue
Hippocampus
Common space
0302 clinical medicine
Cerebellum
Cingulate
2.1 Biological and endogenous factors
Psychology
Aetiology
Child
Lung
Pediatric
Analysis of covariance
Brain Mapping
Sleep Apnea
Obstructive
medicine.diagnostic_test
General Neuroscience
Brain
Cognition
Magnetic Resonance Imaging
Neurological
Cardiology
Biomedical Imaging
Cognitive Sciences
Female
Sleep Research
Acute injury
medicine.medical_specialty
Sleep Apnea
1.1 Normal biological development and functioning
Polysomnography
Prefrontal Cortex
Article
03 medical and health sciences
Clinical Research
Underpinning research
Internal medicine
medicine
Humans
Effects of sleep deprivation on cognitive performance
Obstructive
business.industry
Neurosciences
Magnetic resonance imaging
medicine.disease
Brain Disorders
Obstructive sleep apnea
030228 respiratory system
business
030217 neurology & neurosurgery
Zdroj: Neuroscience Letters. 682:118-123
ISSN: 0304-3940
Popis: Children with long-standing obstructive sleep apnea (OSA) show evidence of neural injury and functional deficits in behavioral and cognitive regulatory brain regions that are reflected in symptoms of altered cognitive performance and behaviors. While we earlier showed reduced gray matter volume and increased and reduced regional cortical thicknesses, such structural changes give little indication of the underlying pathology. Brain tissue integrity in pediatric OSA subjects can reflect the nature and extent of injury or structural adaptation, and can be assessed by entropy tissue texture, a measure of local changes in signal intensity patterns from high-resolution magnetic resonance images. We collected high-resolution T1-weighted magnetic resonance images from 10 pediatric OSA (age, 7.9 ± 1.1 years; apnea-hypopnea-index, 8.8 ± 3.0 events/hour; body-mass-index, 20 ± 6.7 kg/m2; 7 male) and 8 healthy controls (age, 8.8 ± 1.6 years; body-mass-index, 19.6 ± 5.9 kg/m2; 5 female). Images were bias-corrected and entropy maps calculated, individual maps were normalized to a common space, smoothed, and compared between groups (ANCOVA; covariates: age, gender; SPM12, uncorrected-threshold p
Databáze: OpenAIRE
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