The diagnosis of C-kit negative GIST by PDGFRA staining: clinical, pathological, and nuclear medicine perspective
| Autor: | Alper Sevinc, Mustafa Yilmaz, Celalettin Camci, Hakan Buyukhatipoglu |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Leiomyosarcoma
Male Cancer Research Pathology medicine.medical_specialty Stromal cell Receptor Platelet-Derived Growth Factor alpha Gastrointestinal Stromal Tumors PDGFRA medicine Biomarkers Tumor Humans neoplasms Pathological Aged PET-CT GiST Staining and Labeling business.industry Hematology medicine.disease female genital diseases and pregnancy complications digestive system diseases Staining body regions Proto-Oncogene Proteins c-kit Oncology Leiomyoblastomas Positron-Emission Tomography Nuclear medicine business |
| Zdroj: | Onkologie. 30(12) |
| ISSN: | 1423-0240 |
| Popis: | Gastrointestinal stromal tumors (GIST) comprise a majority of tumors previously diagnosed as gastrointestinal leiomyomas, leiomyoblastomas, and leiomyosarcomas. Although GIST may be identified by light microscopy, pathologists commonly employ a panel of immunohistochemical markers to confirm the morphological impression including anti-CD34, smooth-muscle actin, desmin, S100, and CD-117. However, in CD- 117 negative cases, it becomes difficult to diagnose GIST. This is of great importance, since the use of imatinib mesylate has led to a dramatic improvement in survival rates of GIST patients besides improved quality of life.We report the case of a 67-year-old male patient diagnosed as having chemotherapy-resistant metastatic leiomyosarcoma. We reviewed the specimen for a possible diagnosis of c-kit negative GIST. Platelet derived growth factor receptor-alpha (PDGFRA) immunohistochemical stain was recommended. The specimen was positively stained for PDGFRA. Imatinib mesylate (400 mg/d) was started. The patient showed an excellent response after receiving imatinib treatment which was documented with 18 fluoro-deoxyglucose positron emission tomography and computed tomography (18F-FDGPET/ CT) prior to and after treatment.The importance of diagnosis of c-kit negative GIST is emphasized while stressing the importance of PDGFRA staining besides PET/CT response evaluation. |
| Databáze: | OpenAIRE |
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