Spectrum of cutaneous adverse reactions to aromatic antiepileptic drugs and human leukocyte antigen genotypes in Thai patients and meta-analysis
| Autor: | Sadeep Medhasi, Thapanat Nakkrut, Jettanong Klaewsongkram, Ticha Rerkpattanapipat, Chonlaphat Sukasem, Leena Chularojanamontri, Wichai Aekplakorn, Napatra Tovanabutra, Chonlawat Chaichan, Pawinee Rerknimitr, Patompong Satapornpong, Apichaya Puangpetch, Thawinee Jantararoungtong, Thanyada Rungrotmongkol, Kanoot Jaruthamsophon, Naravut Suvannang, Papapit Tuchinda, Napatrupron Koomdee, Sarawut Oo-puthinan, Suthida Sririttha, Surasak Saokaew |
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| Rok vydání: | 2021 |
| Předmět: |
Phenytoin
medicine.medical_specialty Genotype Lamotrigine Risk Assessment 030226 pharmacology & pharmacy Article Prognostic markers 03 medical and health sciences 0302 clinical medicine Gene Frequency Heterocyclic Compounds Risk Factors Internal medicine Genetics medicine Humans Risk factor Oxcarbazepine Pharmacology business.industry Odds ratio Carbamazepine Thailand Prognosis medicine.disease Toxic epidermal necrolysis HLA-B Antigens Case-Control Studies Molecular Medicine Anticonvulsants Phenobarbital Drug Eruptions business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Pharmacogenomics Journal |
| ISSN: | 1473-1150 1470-269X |
| DOI: | 10.1038/s41397-021-00247-3 |
| Popis: | Aromatic antiepileptic drugs (AEDs)-induced cutaneous adverse drug reactions (cADRs) add up to the limited use of the AEDs in the treatment and prevention of seizures. Human leukocyte antigen-B (HLA-B) alleles have been linked to AEDs-induced cADRs. We investigated the association between cADRs (including Stevens–Johnson syndrome; SJS/toxic epidermal necrolysis; TEN, drug reaction with eosinophilia and systemic symptoms; DRESS, and Maculopapular eruption; MPE) caused by AEDs (phenytoin, carbamazepine, lamotrigine, phenobarbital and oxcarbazepine) and HLA-B alleles in Thai population. Through the case-control study, 166 patients with AEDs-induced cADRs, 426 AEDs-tolerant patients (AEDs-tolerant controls), and 470 healthy subjects (Thai population) were collected. The HLA genotypes were detected using the polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) method. We also performed a meta-analysis with these data and other populations. The carrier rate of HLA-B*15:02 was significantly different between AEDs-induced cADRs group and AEDs-tolerant group (Odds ratio; OR 4.28, 95% Confidence interval; CI 2.64–6.95, p p HLA-B*15:02 with AEDs-induced cADRs (OR 4.77, 95%CI 1.79–12.73, p HLA-B*15:02 was associated with SJS/TEN induced by AEDs (OR 10.28, 95%CI 6.50–16.28, p p = 0.001) and carbamazepine (OR 137.69, 95%CI 50.97–371.98, p HLA-B*15:02 and AEDs-induced SJS/TEN was demonstrated with an OR of 10.79 (95%CI 5.50–21.16, p HLA-B*08:01, HLA-B*13:01, and HLA-B*56:02 were significantly higher in the DRESS group compared with the AEDs-tolerant group (p = 0.029, 0.007, and 0.017, respectively). The HLA-B*15:02 allele may represent a risk factor for AEDs-induced cADRs. |
| Databáze: | OpenAIRE |
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