Replication fork reversal in eukaryotes: from dead end to dynamic response
| Autor: | Kai J. Neelsen, Massimo Lopes |
|---|---|
| Přispěvatelé: | University of Zurich, Lopes, Massimo |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
DNA Replication
Replication fork reversal DNA damage Mutant 10061 Institute of Molecular Cancer Research DNA replication Cell Biology Biology Chromatin Conserved sequence Replication fork protection Cell biology 1307 Cell Biology Dead end Genome maintenance 1312 Molecular Biology Animals Humans 570 Life sciences biology Molecular Biology DNA Damage |
| Zdroj: | Nature reviews. Molecular cell biology |
| DOI: | 10.5167/uzh-109568 |
| Popis: | The remodelling of replication forks into four-way junctions following replication perturbation, known as fork reversal, was hypothesized to promote DNA damage tolerance and repair during replication. Albeit conceptually attractive, for a long time fork reversal in vivo was found only in prokaryotes and specific yeast mutants, calling its evolutionary conservation and physiological relevance into question. Based on the recent visualization of replication forks in metazoans, fork reversal has emerged as a global, reversible and regulated process, with intriguing implications for replication completion, chromosome integrity and the DNA damage response. The study of the putative in vivo roles of recently identified eukaryotic factors in fork remodelling promises to shed new light on mechanisms of genome maintenance and to provide novel attractive targets for cancer therapy. |
| Databáze: | OpenAIRE |
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