Impact of hypoxaemia on neuroendocrine function and catecholamine secretion in chronic obstructive pulmonary disease (COPD). Effects of long-term oxygen treatment

Autor: A. Wennlund, T. Bratel, K. Carlström
Rok vydání: 2000
Předmět:
Adult
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Thyroid Hormones
follicle stimulating hormone
medicine.medical_treatment
Neuroendocrinology
sex-hormone binding globulin
chronic obstructive pulmonary disease
hypoxaemia
norepinephrine
Hypoxemia
stress
Follicle-stimulating hormone
thyroxin
Catecholamines
Thyroid-stimulating hormone
Internal medicine
Oxygen therapy
Forced Expiratory Volume
medicine
Humans
epinephrine
Lung Diseases
Obstructive
Gonadal Steroid Hormones
Hypoxia
Aged
COPD
business.industry
Thyroid
Oxygen Inhalation Therapy
thyroid stimulating hormone
Middle Aged
medicine.disease
Neurosecretory Systems
Circadian Rhythm
Endocrinology
medicine.anatomical_structure
Case-Control Studies
testosterone
medicine.symptom
Blood Gas Analysis
business
Gonadotropins
Hormone
Zdroj: Respiratory Medicine. 94(12):1221-1228
ISSN: 0954-6111
DOI: 10.1053/rmed.2000.0953
Popis: The aim of the study was to investigate the effects of chronic hypoxaemia on neuroendocrine function in hypoxaemic chronic obstructive pulmonary disease (COPD). The stress level was assessed by measurement of daytime plasma catecholamine and nocturnal urinary catecholamine levels and endocrine function was assessed by measuring serum gonadotropins, peripheral sex hormones and peripheral thyroid hormones, and by measuring thyroid stimulating hormone (TSH), prolactin and growth hormone before and after thyroid releasing hormone challenge in 12 male, stable, hypoxaemic COPD patients before and after at least 4 months of long-term oxygen treatment (LTOT). Mean pre-treatment P aO2was 7·39±0·78 kPa and mean nocturnal arterial oxygen saturation (MSaO2) was 86·6±3·2%. Plasma norepinephrine (NE) levels were higher than normal, while all other pre-treatment hormone levels were within normal range. Low forced expiratory volume in 1sec (FEV1) was associated with low basal and stimulated TSH (P
Databáze: OpenAIRE
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