Markers of Inflammation and Infection Influence the Outcome of Patients With Baseline Asymptomatic Carotid Lesions

Autor: Ida Maria Muratori, Egle Corrado, Francesca Bonura, Rosalba Tantillo, Giustina Vitale, Manfredi Rizzo, Salvatore Novo
Přispěvatelé: CORRADO, E, RIZZO, M, TANTILLO, R, MURATORI, I, BONURA, F, VITALE, G, NOVO, S
Rok vydání: 2006
Předmět:
Carotid Artery Diseases
Male
Pathology
Time Factors
Cytomegalovirus
Fibrinogen
Cardiovascular System
atherosclerosi
Risk Factors
Stroke
Ultrasonography
Chlamydia
biology
Chlamydophila pneumoniae
Middle Aged
Lipids
Echocardiography
Doppler
C-Reactive Protein
Carotid Arteries
Cardiovascular Diseases
Disease Progression
Female
medicine.symptom
Tunica Media
Cardiology and Cardiovascular Medicine
medicine.drug
medicine.medical_specialty
Congenital cytomegalovirus infection
Infections
Asymptomatic
Central nervous system disease
Sex Factors
Internal medicine
medicine
Humans
carotid arterie
Aged
Advanced and Specialized Nursing
Analysis of Variance
Helicobacter pylori
Vascular disease
business.industry
Atherosclerosis
biology.organism_classification
medicine.disease
infection
inflammation
Immunoglobulin G
Neurology (clinical)
Tunica Intima
business
Follow-Up Studies
Zdroj: Stroke. 37:482-486
ISSN: 1524-4628
0039-2499
Popis: Background and Purpose— It is still in debate whether the evaluation of markers of infection and inflammation may be of importance for cerebrovascular and cardiovascular prevention, and we aimed to investigate this field in a prospective 5-year clinical follow-up study in patients with early stages of atherosclerosis. Methods— We studied 668 subjects divided in 3 groups according to the results of carotid ultrasound examination: (1) normal subjects, if intima-media thickness (IMT) was 1.5 mm. Traditional cardiovascular risk factors were investigated, and laboratory analysis included measurement of plasma lipids, fibrinogen, C-reactive protein, IgG antibodies for helicobacter pylori (HP), cytotoxic HP, cytomegalovirus, and chlamydia pneumoniae . Results— Cerebrovascular or cardiovascular events were registered in 18% of patients during the follow-up, and at multivariate analysis we found that the high levels of fibrinogen ( P P =0.014), the seropositivity to cytotoxic HP ( P =0.001) and chlamydia pneumoniae ( P =0.026), the presence of IMT or asymptomatic carotid plaque ( P P Conclusions— Beyond traditional cardiovascular risk factors, markers of inflammation and infections seem to significantly influence the occurrence of cerebrovascular and cardiovascular events in patients with baseline asymptomatic carotid lesions.
Databáze: OpenAIRE
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