Effects of Epoprostenol on Right Ventricular Hypertrophy and Dilatation in Pulmonary Hypertension
Autor: | Jean G.F. Bronzwaer, Anton Vonk-Noordegraaf, Pieter E. Postmus, J. Tim Marcus, Koen M. Marques, Anco Boonstra, R.J. Roeleveld |
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Přispěvatelé: | Pulmonary medicine, Radiology and nuclear medicine, ACS - Pulmonary hypertension & thrombosis, CCA - Imaging and biomarkers, Cardiology |
Rok vydání: | 2004 |
Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Hypertension Pulmonary Critical Care and Intensive Care Medicine Drug Administration Schedule Statistics Nonparametric Reference Values Right ventricular hypertrophy Internal medicine medicine.artery medicine Humans Prospective Studies Antihypertensive Agents End-systolic volume Aged Probability Ejection fraction Dose-Response Relationship Drug Hypertrophy Right Ventricular Ventricular Remodeling business.industry Stroke volume Middle Aged medicine.disease Epoprostenol Magnetic Resonance Imaging Pulmonary hypertension Treatment Outcome medicine.anatomical_structure Case-Control Studies Anesthesia Heart Function Tests Pulmonary artery Ventricular Function Right Vascular resistance Cardiology Ventricular pressure Female Cardiology and Cardiovascular Medicine business Blood Flow Velocity Dilatation Pathologic Follow-Up Studies |
Zdroj: | Roeleveld, R J, Vonk-Noordegraaf, A, Marcus, J T, Bronzwaer, J G F, Marques, K M J, Postmus, P E & Boonstra, A 2004, ' Effects of Epoprostenol on Right Ventricular Hypertrophy and Dilatation in Pulmonary Hypertension ', Chest, vol. 125, no. 2, pp. 572-579 . https://doi.org/10.1378/chest.125.2.572 Chest, 125(2), 572-579. American College of Chest Physicians |
ISSN: | 0012-3692 |
Popis: | Objectives: To gain more knowledge of changes in main pulmonary artery flow and right ventricular mass and volumes in patients with pulmonary hypertension during epoprostenol therapy. Methods: Eleven patients (9 women) were evaluated before the start of therapy and every 4 months thereafter. Right and left ventricular volumes and masses were measured by cine MRI. Flow was measured with MRI velocity quantification. At the same times, 6-min walking tests were performed. Right-heart catheterizations were performed at baseline and after 1 year. Results: Right ventricular mass in the patient group was significantly higher from that in a control group of healthy volunteers (95 ± 26 g vs 42 ± 10 g, p < 0.05 [mean ± SD]), whereas the stroke volume was lower (34 ± 11 mL vs 81 ± 11 mL, p < 0.05). The greatest improvement in right ventricular stroke volume (to 41 ± 11 mL, p < 0.05) took place in the first 4 months. During the 1-year follow-up, right ventricular end-diastolic volume and mass did not change, and mean pulmonary artery pressure remained nearly stable at 55 mm Hg at baseline and 53 mm Hg after 1 year. Pulmonary vascular resistance decreased by 12.5% (p = 0.06). Conclusions: From these data we conclude that epoprostenol lowers pulmonary vascular resistance, leading to an increase in pulmonary artery flow. This increase in pulmonary artery flow corresponds well with the increase in 6-min walking distance and can be noninvasively monitored by MRI (flow quantification). Right ventricular dilatation and hypertrophy are not reversed by epoprostenol therapy, but do not progress either. |
Databáze: | OpenAIRE |
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