Mortality among individuals exposed to atomic bomb radiation in utero: 1950–2012
| Autor: | Kotaro Ozasa, Munechika Misumi, Alina V. Brenner, Mai Utada, Ritsu Sakata, Hiromi Sugiyama |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Neoplasms Radiation-Induced Adolescent Epidemiology Birth weight In utero exposure Cohort Studies Radiation risk 03 medical and health sciences symbols.namesake Fetus 0302 clinical medicine Japan Radiation Epidemiology Pregnancy Risk Factors medicine Humans 030212 general & internal medicine Poisson regression Mortality Risk factor Child Obstetrics business.industry Atomic bomb survivors Cancer Dose-Response Relationship Radiation Middle Aged Radiation Exposure medicine.disease Confidence interval Low birth weight Maternal Exposure Child Preschool 030220 oncology & carcinogenesis Relative risk symbols Female medicine.symptom business Follow-Up Studies |
| Zdroj: | European Journal of Epidemiology |
| ISSN: | 1573-7284 0393-2990 |
| DOI: | 10.1007/s10654-020-00713-5 |
| Popis: | We examined the mortality risks among 2463 individuals who were exposed in utero to atomic bomb radiation in Hiroshima or Nagasaki in August 1945 and were followed from October 1950 through 2012. Individual estimates of mother’s weighted absorbed uterine dose (DS02R1) were used. Poisson regression method was used to estimate the radiation-associated excess relative risk per Gy (ERR/Gy) and 95% confidence intervals (CI) for cause-specific mortality. Head size, birth weight, and parents’ survival status were evaluated as potential mediators of radiation effect. There were 339 deaths (216 males and 123 females) including deaths from solid cancer (n = 137), lymphohematopoietic cancer (n = 8), noncancer disease (n = 134), external cause (n = 56), and unknown cause (n = 4). Among males, the unadjusted ERR/Gy (95% CI) was increased for noncancer disease mortality (1.22, 0.10–3.14), but not for solid cancer mortality (− 0.18 |
| Databáze: | OpenAIRE |
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