Clinical results and immunologic effects of a mixed bacterial vaccine in cancer patients
Autor: | R S Axelrod, H F Havas, Donna M. Murasko, M M Burns, M Goonewardene |
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Rok vydání: | 1993 |
Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Streptococcus pyogenes medicine.medical_treatment Peripheral blood mononuclear cell Internal medicine Neoplasms medicine Humans Immunologic Factors Serratia marcescens Aged Hematology Performance status business.industry Tumor Necrosis Factor-alpha Cancer Immunotherapy Middle Aged medicine.disease Combined Modality Therapy Bacterial vaccine Oncology Immunology Bacterial Vaccines Interleukin-2 Chills Female Interferons medicine.symptom business Progressive disease |
Zdroj: | Medical oncology and tumor pharmacotherapy. 10(4) |
ISSN: | 0736-0118 |
Popis: | A biological response modifier, mixed bacterial vaccine (MBV), derived from Streptococcus pyogenes and Serratia marcescens was used as a single agent in the treatment of 11 patients with refractory malignancies. MBV's effect on interleukin-2 (IL-2) production, plasma interferon (IFN) and tumor necrosis factor (TNF) levels was monitored. Most patients' peripheral blood mononuclear cells continued to produce baseline to elevated levels of IL-2, in spite of age and disease status. Several patients maintained moderate to high IFN levels. In general there was little correlation between IL-2 and IFN levels or with the response to therapy. One of 11 patients had minor response, 1 of 11 had partial response, 4 of 11 had temporary stabilization of disease, and 5 of 11 had progressive disease. A patient with AIDS and Kaposi's sarcoma experienced a dramatic improvement in performance status and disease stabilization. In all patients side effects occurred only following i.v. and not i.m. administration and included fever and chills. No adverse hepatic, renal or hematologic effects were observed. MBV is a well-tolerated biological response modifier with modest activity in advanced human tumors. |
Databáze: | OpenAIRE |
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