Vertebral bone attenuation in Hounsfield Units and prevalent vertebral fractures are associated with the short-term risk of vertebral fractures in current and ex-smokers with and without COPD: a 3-year chest CT follow-up study

Autor: Frank W.J.M. Smeenk, Piet Geusens, Johanna H M Driessen, Emiel F.M. Wouters, M J van Dort, J. van den Bergh, Elisabeth A. P. M. Romme
Přispěvatelé: Interne Geneeskunde, RS: NUTRIM - R3 - Respiratory & Age-related Health, RS: CAPHRI - R5 - Optimising Patient Care, MUMC+: DA KFT Medische Staf (9), RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, RS: SHE - R1 - Research (OvO), Onderwijs instituut FHML, MUMC+: MA Longziekten (3), Pulmonologie
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Bone density
PREDICTION
Endocrinology
Diabetes and Metabolism
Vital Capacity
Osteoporosis
OSTEOPOROSIS
Pulmonary Disease
Chronic Obstructive
0302 clinical medicine
Bone Density
Forced Expiratory Volume
Mass Screening
DEFORMITIES
DXA
Bone mineral
COPD
Incidence (epidemiology)
MEN
Middle Aged
Tobacco smoking
Screening
Spinal Fractures
Female
Original Article
Radiology
SMOKING
Adult
medicine.medical_specialty
030209 endocrinology & metabolism
Risk Assessment
OBSTRUCTIVE PULMONARY-DISEASE
Thoracic Vertebrae
03 medical and health sciences
Hounsfield scale
medicine
Humans
Aged
business.industry
Fracture risk assessment
GLOBAL BURDEN
medicine.disease
Orthopedic surgery
MINERAL DENSITY
030101 anatomy & morphology
Ex-Smokers
Tomography
X-Ray Computed
business
Body mass index
Osteoporotic Fractures
Follow-Up Studies
Zdroj: Osteoporosis International, 30(8), 1561-1571. Springer-Verlag London Ltd.
Osteoporosis International
ISSN: 1433-2965
0937-941X
DOI: 10.1007/s00198-019-04977-w
Popis: Summary CT scans performed to evaluate chronic obstructive pulmonary disease (COPD) also enable evaluation of bone attenuation (BA; a measure of bone density) and vertebral fractures (VFs). In 1239 current/former smokers with (n = 999) and without (n = 240) COPD, the combination of BA and prevalent VFs was associated with the incident VF risk. Introduction Chest CT scans are increasingly used to evaluate pulmonary diseases, including COPD. COPD patients have increased risk of osteoporosis and VFs. BA on CT scans is correlated with bone mineral density and prevalent VFs. The aim of this study was to evaluate the association between BA and prevalent VFs on chest CT scans, and the risk of incident VFs in current and former smokers with and without COPD. Methods In participants of the ECLIPSE study with baseline and 1-year and 3-year follow-up CT scans, we evaluated BA in vertebrae T4–T12 and prevalent and incident VFs. Results A total of 1239 subjects were included (mean age 61.3 ± 8.0, 61.1% men, 999 (80.6%) COPD patients). The mean BA was 155.6 ± 47.5 Hounsfield Units (HU); 253 (20.5%) had a prevalent VF and 296 (23.9%) sustained an incident VF within 3 years. BA and prevalent VFs were associated with incident VFs within 1 (per − 1SD HR = 1.38 [1.08–1.76] and HR = 3.97 [2.65–5.93] resp.) and 3 years (per − 1SD HR = 1.25 [1.08–1.45] and HR = 3.10 [2.41–3.99] resp.), while age, sex, body mass index (BMI), smoking status and history, or presence of COPD was not. In subjects without prevalent VFs and BA, and for 1-year incidence, BMI values were associated with incident fractures (1 year, BA per − 1SD HR = 1.52 [1.05–2.19], BMI per SD HR = 1.54 [1.13–2.11]; 3 years, per − 1SD HR = 1.37 [1.12–1.68]). Conclusions On CT scans performed for pulmonary evaluation in (former) smokers with and without COPD, the combination of BA and prevalent VFs was strongly associated with the short-term risk of incident VFs. Electronic supplementary material The online version of this article (10.1007/s00198-019-04977-w) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
Externí odkaz: