Anal cancer in women
| Autor: | Deborah Borek, Abbas M. Behbehani, James A. Fishback, Frederick F. Holmes, Ariel B. Baker, Grace F. Holmes, Ruth S. Hassanein, Medge Owen-Kummer |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
medicine.medical_specialty Alcohol Drinking Sexual Behavior Population Papanicolaou stain Logistic regression Antibodies Viral Coffee Hemorrhoids Risk Factors Internal medicine Medicine Anal cancer Humans Simplexvirus Risk factor education Defecation Papillomaviridae Aged Aged 80 and over education.field_of_study Univariate analysis Carcinoma Transitional Cell Hepatology business.industry Cathartics Smoking Gastroenterology Middle Aged medicine.disease Anus Anus Neoplasms Surgery medicine.anatomical_structure Carcinoma Squamous Cell Female Viral disease business |
| Zdroj: | Gastroenterology. 95(1) |
| ISSN: | 0016-5085 |
| Popis: | We studied predisposing factors in 56 women with anal cancer, comparing them with 56 matched controls drawn from the population. A detailed pretested questionnaire was administered to each study subject in a structured interview and blood was drawn for detection of herpes simplex virus antibodies by radioimmunoassay. Pathologic material from cases was obtained and evidence of human papilloma virus infection was sought. By univariate analyses we found associations between anal cancer and positive herpes simplex virus 2 titer (p = 0.0017), cigarette smoking (p = 0.0028), previous positive or questionable cervical Papanicolaou smear (p = 0.0124), and increasing number of sexual partners (p = 0.0224). By the multivariate technique of logistic regression there were independent and significant associations with cigarette smoking (p = 0.0126), previous use of hemorrhoid preparations (p = 0.0149), and history of disturbed bowel habits for greater than 1 mo (p = 0.0273). Anal cancer in women is a rare disease associated with cigarette smoking and sexual experience. Its association with previous anorectal disease is unclear and deserving of further study. |
| Databáze: | OpenAIRE |
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