Haplotype Analysis of GSK-3β Gene Polymorphisms in Bipolar Disorder Lithium Responders and Nonresponders
| Autor: | Shin Narita, Fumihiko Fukamauchi, Daisuke Nishizawa, Kenta Nagahori, Maki Numajiri, Ohoshi Murayama, Jun Ishigooka, Eiji Yoshihara, Kazuhiko Iwahashi, Kazutaka Ikeda, Yuuya Onozawa |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Linkage disequilibrium medicine.medical_specialty Lithium (medication) Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Glycogen Synthase Kinase 3 chemistry.chemical_compound Japan Antimanic Agents Internal medicine medicine Humans Pharmacology (medical) Bipolar disorder Genetic Association Studies bipolar disorder Pharmacology Genetics Valproic Acid Glycogen Synthase Kinase 3 beta GSK-3β Haplotype Original Articles medicine.disease Endocrinology Haplotypes chemistry Pharmacogenetics Lithium chloride Female Neurology (clinical) Lithium Chloride lithium response medicine.drug |
| Zdroj: | Clinical Neuropharmacology |
| ISSN: | 0362-5664 |
| DOI: | 10.1097/wnf.0000000000000039 |
| Popis: | The GSK-3β gene, GSK3B, codes for an enzyme that is a target for the action of mood stabilizers, lithium and possibly valproic acid. In this study, the relationship between haplotypes consisting of single nucleotide polymorphisms (SNPs) of GSK3B −50T/C and −1727A/T and the effect of lithium was studied among Japanese bipolar disorder lithium nonresponders and responders. The distributions of the GSK3B haplotypes (−50T/C and −1727A/T) showed a trend for significant difference between the lithium nonresponders and responders (global P=0.07074). Haplotype 1 (T-A) was associated with a higher lithium response (haplotype-specific P=0.03477), whereas haplotype 2 (C-A) was associated with a lower lithium response (haplotype-specific P=0.03443). The pairwise D′ and r2 values between the 2 SNPs in this study were 1.0 and 0.097, respectively. The 2 SNPs showed weak linkage disequilibrium with each other. |
| Databáze: | OpenAIRE |
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