Coronary heart disease and urinary albumin excretion rate in Type 2 (non-insulin-dependent) diabetic patients
| Autor: | Martin B Mattock, G. S. Scott, Harry Keen, J. R. Wing, M. R. El-Gohari, P. G. Jackson, T. J. Murrells, Gc Viberti |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Blood Pressure Coronary Disease Urine Lipoproteins VLDL Gastroenterology Excretion chemistry.chemical_compound Risk Factors Diabetes mellitus Internal medicine Internal Medicine Albuminuria Humans Medicine Triglycerides Glycated Hemoglobin Sex Characteristics Proteinuria business.industry Cholesterol Cholesterol HDL Albumin Middle Aged medicine.disease Confidence interval Kinetics Blood pressure Endocrinology Diabetes Mellitus Type 2 chemistry Regression Analysis Female medicine.symptom business |
| Zdroj: | Diabetologia. 31:82-87 |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/bf00395552 |
| Popis: | Associations between overnight urinary albumin excretion rate and prevalent coronary heart disease and its major risk factors were examined in a cross-sectional study of 141 Type 2 (non-insulin-dependent) diabetic patients. Mean albumin excretion rate was higher in men (geometric mean 13.5 micrograms/min; 95% confidence interval 10.3-17.6) than women (7.5 micrograms/min; 5.7-9.8, p less than 0.01). In diabetic men and women mean albumin excretion rate was higher in those with electrocardiographic and/or symptomatic evidence of coronary heart disease than in those without (men, 23.1 micrograms/min; 95% confidence interval 13.7-39.0 versus 10.6 micrograms/min; 7.9-14.2, p less than 0.01, women, 13.7 micrograms/min; 8.0-23.5 versus 5.4 micrograms/min; 4.2-6.8, p less than 0.01). Multiple logistic regression analysis was used to allow for confounding between variables. In the diabetic group as a whole, raised albumin excretion rate (p less than 0.001), gender (p less than 0.05) and systolic blood pressure (p = 0.06) entered the "best" model for coronary heart disease prediction. In women, albumin excretion rate alone (p less than 0.01) and in men albumin excretion rate (p less than 0.01) and age (p = 0.05) entered the "best" models. We conclude that albumin excretion rate is significantly associated with coronary heart disease morbidity after taking into account the confounding effects of raised blood pressure and other cardiovascular risk factors. |
| Databáze: | OpenAIRE |
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