Microarray profiling of colorectal cancer in Bangladeshi patients
| Autor: | Stephen A. Bustin, Sina Dorudi, Ayan Banerjea, R. E. Hands, S. Ahmed |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Microarray Colorectal cancer Population Ethnic group Disease Internal medicine Humans Medicine Family history education Aged Oligonucleotide Array Sequence Analysis Bangladesh education.field_of_study business.industry Gene Expression Profiling Gastroenterology Cancer Middle Aged medicine.disease humanities Gene expression profiling population characteristics Female Colorectal Neoplasms business geographic locations |
| Zdroj: | Colorectal Disease. 7:571-575 |
| ISSN: | 1463-1318 1462-8910 |
| Popis: | Objective We have carried out a retrospective analysis of all cases of colorectal cancer at the Royal London Hospital between April 1998 and March 2002 and determined the differences in presentation and outcome between Bangladeshi and Non-Bangladeshi patients. DNA microarrays were used to explain any potential genetic differences between these two groups that may explain the different phenotypes. Materials and methods We examined the colorectal database at our institution. Microarray profiles, using Affymetrix HU133A Genechips TM (Santa Clara, CA USA) were obtained from 10 Bangladeshi patients and an age-, sex- and stage-matched group of 10 NonBangladeshi patients. Results Three hundred and sixty-three patients have been treated for colorectal cancer at the Royal London Hospital. Eighteen (5%) patients were of Bangladeshi origin. The prevalence was 27 ⁄ 100 000 compared to 342 ⁄ 100 000 of the Non-Bangladeshi population. Eleven (61%) of 18 Bangladeshi patients were under the age of 40 and 4 (22%) patients presented with locally advanced or metastatic disease. In comparison 39 ⁄ 345 (11%) of non-Bangladeshi patients presented with advanced disease. None of the Bangladeshi patients gave a positive family history. Microarray profiling between these two groups demonstrated 1203 differentially expressed genes ( P< 0.05). Conclusion Colorectal cancer is uncommon in the Bangladeshi patients compared to the non-Bangladeshi population. This cancer presents in younger patients and at a more advanced stage. There is no positive family history within this ethnic community and therefore the cancers are sporadic. However, microarray profiling is able to delineate different gene expression between these two groups. Therefore, there should be a low threshold for investigating young Bangladeshi patients with symptoms of colorectal neoplasia and any future national screening programme should allow for ethnic variation. |
| Databáze: | OpenAIRE |
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