Mechanochemical synthesis, characterization and thermoanalytical study of a new curcumin derivative
| Autor: | Flávio Junior Caires, Luiz Carlos da Silva-Filho, Caroline Gaglieri, Aniele de Moura |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
biology
4-Carboxybenzaldehyde Condensed Matter Physics biology.organism_classification Combinatorial chemistry Characterization (materials science) chemistry.chemical_compound Solid–solid phase transition chemistry Curcuminoids Knoevenagel reaction Curcumin Proton NMR Knoevenagel condensation Thermal analysis Physical and Theoretical Chemistry Curcuma Fourier transform infrared spectroscopy Mechanochemistry |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2020-12-12T01:30:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 The curcumin is the major constituent of turmeric plant (Curcuma longa), which presents several biological activities such as antioxidant, bactericidal, anti-inflammatory and antitumor. An interesting strategy to improve its properties is to synthetize curcumin derivatives. Thus, the synthesis of a new curcumin derivative (DCUR) with 4-carboxybenzaldehyde (4-CBA) becomes interesting, which occurs by a Knoevenagel reaction, a common methodology used to synthesize curcumin analogues. The synthesis was carried out by the mechanochemical method, which is an efficient green method for the synthesis of organic compounds. The most efficient grinding time for mechanochemical synthesis was determined using PXRD and DSC techniques. 1H NMR, DEPTQ and FTIR analyses confirmed the structure of DCUR. This new methodology is more efficient (at least 5×), and cleaner than usual methods described in the literature to obtain a new compound by Knoevenagel reaction. The TG–DTA, DSC and DSC-microscopy techniques were used to confirm the formation of the compound and to study its thermal behavior. Moreover, the thermoanalytical of 4-CBA showed that this compound presents a reversible solid–solid phase transition. Chemistry Department School of Sciences UNESP - São Paulo State University Chemistry Department School of Sciences UNESP - São Paulo State University |
| Databáze: | OpenAIRE |
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