Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin
| Autor: | Matilda Vojnovic, Janka Zlinská, Mira Popovic, Jovanka Kolarovic, Svetlana Trivić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Antioxidant
Antioxidative status medicine.medical_treatment Cyt P450 Pharmaceutical Science celery and parsley juices Plant Roots doxorubicin Antioxidants Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Cytochrome P-450 Enzyme System Drug Discovery medicine polycyclic compounds Animals Doxorubicin Drug Interactions Food science Physical and Theoretical Chemistry reduced glutathione Medicinal plants Apium Antibiotics Antineoplastic biology Organic Chemistry FRAP Cytochrome P450 food and beverages Glutathione Rats Plant Leaves chemistry Biochemistry Liver Chemistry (miscellaneous) biology.protein Molecular Medicine Ferric Petroselinum CELERY JUICE medicine.drug |
| Zdroj: | Molecules; Volume 15; Issue 9; Pages: 6193-6204 Molecules Molecules, Vol 15, Iss 9, Pp 6193-6204 (2010) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules15096193 |
| Popis: | We have examined the influence of diluted pure celery and parsley leaf and root juices and their combinations with doxorubicin on the antioxidant status [as measured by the content of reduced glutathione (GSH) and ferric reducing antioxidant power (FRAP)] in liver homogenate and hemolysate and on the contents of cytochrome P450 in liver homogenate. It was found that doxorubicin significantly decreased the content of reduced glutathione and the total antioxidative status (FRAP) in liver homogenate and hemolysate, while celery and parsley juices alone and in combination with doxorubicin had different actions. Doxorubicin and celery juice had no effect on content of cytochrome P450. However, in combination with doxorubicin, parsley root juice significant increased, and parsley leaves juice decreased the cytochrome P450 content (compared to doxorubicin treated animals). Only parsley root juice significantly increased the content of cytochrome P450. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|