Decreased Brain-Derived Neurotrophic Factor Serum Concentrations in Chronic Post-Stroke Subjects

Autor: Gabriela Lopes dos Santos, Carolina Carmona Alcântara, Thiago Luiz Russo, Luisa Fernanda García-Salazar, Marcela A. Silva-Couto
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Time Factors
Physiology
Disability Evaluation
0302 clinical medicine
Quality of life
Risk Factors
Neurotrophic factors
Surveys and Questionnaires
Stroke
Neurologic Examination
medicine.diagnostic_test
Rehabilitation
Age Factors
Stroke Rehabilitation
Venous blood
Middle Aged
Treatment Outcome
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Down-Regulation
Enzyme-Linked Immunosorbent Assay
Physical examination
Motor Activity
03 medical and health sciences
medicine
Humans
Mobility Limitation
Aged
Brain-derived neurotrophic factor
business.industry
Brain-Derived Neurotrophic Factor
Recovery of Function
medicine.disease
Cross-Sectional Studies
030104 developmental biology
Hemiparesis
Case-Control Studies
Chronic Disease
Quality of Life
Physical therapy
Surgery
Neurology (clinical)
business
Body mass index
Biomarkers
030217 neurology & neurosurgery
Zdroj: Journal of Stroke and Cerebrovascular Diseases. 25:2968-2974
ISSN: 1052-3057
Popis: Brain-derived neurotrophic factor (BDNF) plays a critical role in sensorimotor recovery after a stroke. However, few studies have assessed the circulating BDNF levels in post-stroke humans to understand its changes. This study was conducted to measure BDNF serum concentrations in subjects with chronic hemiparesis, as well as to correlate serum concentrations with age, post-stroke time, total score of Stroke Specific Quality of Life Scale (SS-QOL), mobility subscale score, and motor function of SS-QOL.Seventeen chronic post-stroke subjects matched by age and gender with healthy controls took part in the study. Personal data (age, hemiparesis side, and post-stroke time) were collected, and a physical examination (weight, height, body mass index) and SS-QOL assessment were carried out. On the same day, after the initial evaluation, venous blood samples were collected from the chronic post-stroke subjects and the healthy subjects. The BDNF serum concentrations were measured blindly by enzyme-linked immunosorbent assay.Subjects with chronic hemiparesis presented a decrease in BDNF serum compared with healthy subjects (P .01). There was no correlation between BDNF serum levels with post-stroke time, age or quality of life, mobility, and the upper extremity motor function (P .05). BDNF concentrations are related to structural and functional recovery after stroke; thus, this reduction is important to understand the rehabilitation process more clearly. However, more studies are needed considering the genetic variations and other tools to assess motor impairment and functional independence.Chronic post-stroke subjects presented a decrease in BDNF serum concentrations, without a correlation with post-stroke time, age, and quality of life.
Databáze: OpenAIRE
Externí odkaz: