Epilepsy in Neurodegenerative Dementias: A Clinical, Epidemiological, and EEG Study
| Autor: | Matteo Pardini, Francesco Famà, Elisa Doglione, Laura Filippi, Flavio Villani, Flavio Nobili, Stefano Grisanti, Riccardo Meli, Federico Massa, Andrea Brugnolo, Michele Terzaghi, Andrea Donniaquio, Nicola Girtler, Pietro Mattioli, Matteo Grazzini, Dario Arnaldi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Pediatrics Neuropsychological Tests Primary progressive aphasia Cohort Studies Epilepsy 0302 clinical medicine Positron Emission Tomography Computed Tomography Prevalence Neuropsychological assessment EEG Aged 80 and over medicine.diagnostic_test General Neuroscience Neuropsychology Electroencephalography Neurodegenerative Diseases General Medicine Middle Aged Mental Status and Dementia Tests Magnetic Resonance Imaging Psychiatry and Mental health Clinical Psychology Frontotemporal Dementia Cohort Anticonvulsants Female Alzheimer’s disease Frontotemporal dementia Lewy Body Disease medicine.medical_specialty seizure 03 medical and health sciences Alzheimer Disease mental disorders medicine Dementia Humans Aged business.industry Dementia with Lewy bodies medicine.disease 030104 developmental biology dementia epilepsy Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's disease : JAD. 74(3) |
| ISSN: | 1875-8908 |
| Popis: | Background Seizures are common in patients with dementia but precise epidemiologic data of epilepsy in neurodegenerative dementia is lacking. Objective The first aim of the study was to investigate prevalence and clinical characteristics of epilepsy in a large cohort of patients with neurodegenerative dementias. Subsequently, we explored clinical, neuropsychological, and quantitative electroencephalogram (qEEG) data of Alzheimer's disease (AD) patients with epilepsy (AD-EPI) as compared to AD patients without epilepsy (AD-CTR). Methods We retrospectively evaluated consecutive patients with a diagnosis of a neurodegenerative dementia and a clinically diagnosed epilepsy that required antiepileptic drugs (AED). All patients underwent baseline comprehensive neuropsychological assessment. A follow-up of at least one year was requested to confirm the dementia diagnosis. In AD patients, qEEG power band analysis was performed. AD-CTR and AD-EPI patients were matched for age, Mini-Mental State Examination score, and gender. Results Thirty-eight out of 2,054 neurodegenerative dementia patients had epilepsy requiring AED. The prevalence of epilepsy was 1.82% for AD, 1.28% for the behavioral variant of frontotemporal dementia (bvFTD), 2.47% for dementia with Lewy bodies (DLB), and 12% for primary progressive aphasia. Epilepsy were more drug-responsive in AD than in non-AD dementias. Finally, no significant differences were found in neuropsychological and qEEG data between AD-EPI and AD-CTR patients. Conclusion In our cohort, AD, FTD, and DLB dementias have similar prevalence of epilepsy, even if AD patients were more responsive to AED. Moreover, AD-EPI patients did not have significant clinical, neuropsychological qEEG differences compared with AD-CTR patients. |
| Databáze: | OpenAIRE |
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