THE ASSOCIATION BETWEEN VITAMIN D LEVELS AND HANDGRIP STRENGTH IN ELDERLY MEN
| Autor: | Burcin M. Atak, I E Ozcil, Gulali Aktas, Ozge Kurtkulagi, Satilmis Bilgin, Duman Tt, Kocak Mz |
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| Přispěvatelé: | BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aktaş, Gülali, Duman, Tuba Taslamacıoğlu, Kurtkulağı, Özge, Özçil, İrem Emir, Atak, Burçin Meryem, Bilgin, Satılmış |
| Rok vydání: | 2020 |
| Předmět: |
Notes and Comments
Weakness medicine.medical_specialty Endocrine and Autonomic Systems business.industry Endocrinology Diabetes and Metabolism medicine.medical_treatment Muscle weakness Context (language use) Calcitriol receptor Steroid hormone Endocrinology Internal medicine Vitamin D and neurology Handgrip Stress Test Medicine Population study Muscle Strength Vitamin D medicine.symptom business Body mass index |
| Zdroj: | Acta Endocrinol (Buchar) |
| ISSN: | 1841-0987 |
| Popis: | WOS:000597111200023 PubMed: 33029248 Context. Vitamin D is a steroid hormone that acts by binding to the vitamin D receptor (VDR) found in many tissues. According to the long-term mechanism, vitamin D causes the proliferation and differentiation of muscle cells by gene transcription. Objective. We aimed to evaluate the relationship between muscle strength and serum vitamin D levels in elderly men. Design. Cross-sectional study. Subjects and Methods. Male patients over age 50 were included in the study. Study population was divided into 2 groups with handgrip strength according to body mass index, either as subjects with weak or with normal handgrip strength test (HGST). Vitamin D levels and other variables compared between weak and normal groups. Results. Vitamin D level of weak and normal groups were 75 (3-19.9) mu g/L, and 11.6 (11.6-34.9) mu g/L, which means significant reduced vitamin D levels in weakness group (p=0.01). Vitamin D levels were significantly correlated with HGST levels (r:0.362, p=0.001). Vitamin D levels were found to be an independent predictor of weakness according to HGST in logistic regression analysis (OR: 0.453, 95% CI:0.138-0.769, p=0.05). Conclusions. Low vitamin D level is an independent risk factor for muscle weakness in men aged more than 50 years. Therefore, vitamin D levels should be screened and early replacement should be initiated for the sake of improvement of muscle strength in elderly subjects that vulnerable for frailty. |
| Databáze: | OpenAIRE |
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