A rare human variant that disrupts GPR10 signalling causes weight gain in mice
| Autor: | Talbot, Fleur, Feetham, Claire H, Mokrosiński, Jacek, Lawler, Katherine, Keogh, Julia M, Henning, Elana, Mendes De Oliveira, Edson, Ayinampudi, Vikram, Saeed, Sadia, Bonnefond, Amélie, Arslan, Mohammed, Yeo, Giles S H, Froguel, Philippe, Bechtold, David A, Adamson, Antony, Humphreys, Neil, Barroso, Inês, Luckman, Simon M, Farooqi, I Sadaf |
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| Přispěvatelé: | Talbot, Fleur [0000-0002-8897-4103], Mokrosiński, Jacek [0000-0001-5008-0457], Lawler, Katherine [0000-0003-4188-1804], Mendes de Oliveira, Edson [0000-0002-7330-7826], Saeed, Sadia [0000-0003-3144-7772], Yeo, Giles SH [0000-0001-8823-3615], Froguel, Philippe [0000-0003-2972-0784], Bechtold, David A [0000-0001-8676-8704], Adamson, Antony [0000-0002-5408-0013], Barroso, Inês [0000-0001-5800-4520], Farooqi, I Sadaf [0000-0001-7609-3504], Apollo - University of Cambridge Repository |
| Rok vydání: | 2023 |
| Předmět: |
Multidisciplinary
Obesity/genetics General Physics and Astronomy Mice Transgenic General Chemistry Weight Gain Weight Gain/genetics General Biochemistry Genetics and Molecular Biology Receptors G-Protein-Coupled Mice Animals Humans Obesity Receptors G-Protein-Coupled/genetics Energy Metabolism Signal Transduction |
| Zdroj: | Talbot, F, Feetham, C H, Mokrosiński, J, Lawler, K, Keogh, J M, Henning, E, Mendes de Oliveira, E, Ayinampudi, V, Saeed, S, Bonnefond, A, Arslan, M, Yeo, G S H, Froguel, P, Bechtold, D A, Adamson, A, Humphreys, N, Barroso, I, Luckman, S M & Farooqi, I S 2023, ' A rare human variant that disrupts GPR10 signalling causes weight gain in mice ', Nature Communications, vol. 14, no. 1, 1450 . https://doi.org/10.1038/s41467-023-36966-3 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-023-36966-3 |
| Popis: | Funder: Wellcome Trust Disruption of brain-expressed G protein-coupled receptor-10 (GPR10) causes obesity in animals. Here, we identify multiple rare variants in GPR10 in people with severe obesity and in normal weight controls. These variants impair ligand binding and G protein-dependent signalling in cells. Transgenic mice harbouring a loss of function GPR10 variant found in an individual with obesity, gain excessive weight due to decreased energy expenditure rather than increased food intake. This evidence supports a role for GPR10 in human energy homeostasis. Therapeutic targeting of GPR10 may represent an effective weight-loss strategy. |
| Databáze: | OpenAIRE |
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