Characterization of ocular and nasopharyngeal microbiome in allergic rhinoconjunctivitis
| Autor: | Ka Wai Kam, Stephen Kwok-Wing Tsui, Jinpao Hou, Vishal Jhanji, Ting Fan Leung, Jennifer Wing-Ki Yau, Kam Lun Hon, Nam Sze Cheng, Jason C. S. Yam |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Allergy Adolescent Immunology Allergic condition Eye 03 medical and health sciences Feces 0302 clinical medicine Nasopharynx RNA Ribosomal 16S Immunology and Allergy Medicine Humans 030212 general & internal medicine Microbiome Child Moraxella Conjunctivitis Allergic Arc (protein) biology Host Microbial Interactions business.industry Microbiota Pharynx Case-control study Bacteroidetes biology.organism_classification medicine.disease Rhinitis Allergic medicine.anatomical_structure Cross-Sectional Studies 030228 respiratory system Pediatrics Perinatology and Child Health Dysbiosis Female business |
| Zdroj: | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and ImmunologyREFERENCES. 30(6) |
| ISSN: | 1399-3038 |
| Popis: | BACKGROUND Allergic rhinoconjunctivitis (ARC) is a prevalent allergic condition in the pediatric population. Microbial dysbiosis has increasingly been recognized to influence on host immunity and allergic diseases. However, the microbial profile of ARC has not been characterized. This cross-sectional study aims to evaluate the changes in nasal and ocular surface microbiome of children with ARC. METHODS Ocular and nasopharyngeal swabs were collected from controls and pediatric ARC cases for 16S rRNA amplicon sequencing. The bacterial community profile was analyzed. The correlation of the microbial diversity with the ARC-related clinical scores was studied. RESULTS A total of 23 patients with ARC and 17 healthy controls were recruited;30 were ocular samples (15 controls vs 15 ARC), while 40 were nasal samples (17controls vs 23 ARC) The alpha diversity of nasopharyngeal microbiome was significantly higher in ARC patients than healthy controls (P |
| Databáze: | OpenAIRE |
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