Age at menarche is not an independent risk factor for high-risk human papillomavirus infections and cervical intraepithelial neoplasia
| Autor: | Oksana Erokhina, J. Podistov, Rosa Santopietro, Julia Pajanidi, Piero Tosi, Nicolay Petrovichev, Maritta Nikitina, Alla Pshepurko, Marcella Cintorino, Galina Chemeris, Raisa Nerovjna, Tatjana Zakharova, Anna Juschenko, Ludmila Kljukina, Valerija Grunberga, Irena Shabalova, Alexandr Grunberg, Olga Ivanchenko, Larisa Sozaeva, Marina Branovskaja, Stina Syrjänen, Sergej Zakharenko, Elena Lipova, Vladimir Kozachenko, Irena Tsidaeva, Kari Syrjänen |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Sexually transmitted disease medicine.medical_specialty Time Factors Multivariate analysis Adolescent Sexual Behavior Population Dermatology Cervical intraepithelial neoplasia Pregnancy Risk Factors medicine Humans Pharmacology (medical) Risk factor education Papillomaviridae Cervix Aged Aged 80 and over Menarche Vaginal Smears Gynecology Cervical cancer education.field_of_study business.industry Papillomavirus Infections Age Factors Public Health Environmental and Occupational Health virus diseases Middle Aged Delivery Obstetric Uterine Cervical Dysplasia medicine.disease female genital diseases and pregnancy complications Infectious Diseases medicine.anatomical_structure Multivariate Analysis Female business Papanicolaou Test |
| Zdroj: | International Journal of STD & AIDS. 19:16-25 |
| ISSN: | 1758-1052 0956-4624 |
| DOI: | 10.1258/ijsa.2007.007042 |
| Popis: | Data are controversial as to the role of menarche age as a risk factor of high-risk human papillomavirus (HR-HPV) infections. The objective of this study was to analyse the risk estimates for age at menarche as determinant of cervical intraepithelial neoplasia (CIN) and HR-HPV infections. A cohort of 3187 women were stratified into three groups according to their age at menarche: (i) women 15 years of age. These groups were analysed for predictors of (a) HR-HPV, (b) high-grade CIN and (c) outcome of HR-HPV and cytological abnormalities during prospective follow-up. All the three groups had identical prevalence of HR-HPV, Papanicolaou smear abnormalities and CIN grades. In contrast to menarche age itself, the time from menarche to the first intercourse (TMI), to the first pregnancy (TMP) and to the first delivery (TMD) were all significant ( P = 0.0001) predictors of HR-HPV (but not CIN2) in univariate analysis, but lost their significance in a multivariate model. Outcome of cervical disease and HR-HPV infection was unrelated to menarche age, the latter and the three intervals being not predictors of CIN2 in a multivariate model. In conclusion, age at menarche and the intervals between menarche and (i) onset of sexual activity, (ii) first pregnancy and iii) first delivery, are not independent predictors of HR-HPV infections and CIN2 in multivariate analysis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|