Genetic Testing in Clinical Settings
| Autor: | Nora Franceschini, Amber Frick, Jeffrey B. Kopp |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions Health literacy Disease 030204 cardiovascular system & hematology Social issues Risk Assessment Article Efficacy 03 medical and health sciences 0302 clinical medicine Health care medicine Humans 030212 general & internal medicine Genetic Testing Practice Patterns Physicians' Renal Insufficiency Chronic Intensive care medicine Genetic testing Aged medicine.diagnostic_test business.industry Multimorbidity United States Nephrology Pharmacogenetics Pharmacogenomics Drug Therapy Combination business Needs Assessment |
| Popis: | Genetic testing is used for screening, diagnosis, and prognosis of diseases consistent with a genetic cause and to guide drug therapy to improve drug efficacy and avoid adverse effects (pharmacogenomics). This In Practice review aims to inform about DNA-related genetic test availability, interpretation, and recommended clinical actions based on results using evidence from clinical guidelines, when available. We discuss challenges that limit the widespread use of genetic information in the clinical care setting, including a small number of actionable genetic variants with strong evidence of clinical validity and utility, and the need for improving the health literacy of health care providers and the public, including for direct-to-consumer tests. Ethical, legal, and social issues and incidental findings also need to be addressed. Because our understanding of genetic factors associated with disease and drug response is rapidly increasing and new genetic tests are being developed that could be adopted by clinicians in the short term, we also provide extensive resources for information and education on genetic testing. |
| Databáze: | OpenAIRE |
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