Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement
| Autor: | Gleb P. Shumyatsky, Shusaku Uchida |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Article Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine Memory Transcription (biology) Animals Humans Epigenetics Gene biology General Neuroscience Brain FGF1 Chromatin Cell biology 030104 developmental biology Histone Gene Expression Regulation Transcription Coactivator DNA methylation biology.protein Fibroblast Growth Factor 1 030217 neurology & neurosurgery Transcription Factors |
| Zdroj: | Brain Research Bulletin. 141:3-12 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/j.brainresbull.2018.02.016 |
| Popis: | Recent evidence demonstrates that epigenetic regulation of gene transcription is critically involved in learning and memory. Here, we discuss the role of histone acetylation and DNA methylation, which are two best understood epigenetic processes in memory processes. More specifically, we focus on learning-strength-dependent changes in chromatin on the fibroblast growth factor 1 (Fgf1) gene and on the molecular events that modulate regulation of Fgf1 transcription, required for memory enhancement, with the specific focus on CREB-regulated transcription coactivator 1 (CRTC1). |
| Databáze: | OpenAIRE |
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