Synthesis and Antileishmanial Activity of Lipidic Amino Alcohols
| Autor: | Elaine Soares Coimbra, Adilson David da Silva, Ana C. F. De Almeida, Aline F. Taveira, Celso O. R. Junior, Cristiane F. da Costa, Mauro V. de Almeida, Elaine F. C. Reis |
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| Rok vydání: | 2010 |
| Předmět: |
Leishmania
Pharmacology Stereochemistry Organic Chemistry Leishmaniasis Leishmania chagasi Biology medicine.disease Reference drug Amino Alcohols Trypanocidal Agents Biochemistry In vitro Amphotericin B parasitic diseases Drug Discovery Lipophilicity medicine Humans Molecular Medicine Potency IC50 medicine.drug |
| Zdroj: | Chemical Biology & Drug Design. 75:233-235 |
| ISSN: | 1747-0285 1747-0277 |
| DOI: | 10.1111/j.1747-0285.2009.00923.x |
| Popis: | In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC(50) below 10 microm. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms. |
| Databáze: | OpenAIRE |
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