Distribution and properties of rat intestinal alkaline phosphatase isoenzymes
| Autor: | Noboru Niwa, Takashi Hayakawa, Haruhito Tsuge, Hiroshi Wada, Ikuo Yagami |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
musculoskeletal diseases
Male Intestinal alkaline phosphatase Alp activity Biology Isozyme General Biochemistry Genetics and Molecular Biology stomatognathic system medicine Distribution (pharmacology) Animals Tissue Distribution Enzyme Inhibitors Rats Wistar Kidney Rat intestine General Veterinary musculoskeletal neural and ocular physiology General Medicine musculoskeletal system Alkaline Phosphatase Molecular biology Homoarginine Rats Intestines Isoenzymes Molecular Weight medicine.anatomical_structure Biochemistry Animal Science and Zoology Electrophoresis Polyacrylamide Gel |
| Zdroj: | Experimental animals. 50(2) |
| ISSN: | 1341-1357 |
| Popis: | The ALP activities and properties of rat intestine cut into 20 segments were examined, and we were able to demonstrate that the ALP activity of upper intestine is high compared to that of lower intestine. This result coincided with those of other reports. However, we newly clarified that there is an ALP isoenzyme found in the lower intestine which can be inhibited by L-homoarginine. The molecular weight of the ALP isoenzyme was 136 kDa. In addition, it was clarified that there are several isoenzymes from upper to lower intestine. This study demonstrates that there exist isoenzymes, which are inhibited by L-HArg, in the intestine which are similar to the isoenzymes in the liver, bone and kidney. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|