Acid–base regulation and sensing: Accelerators and brakes in metabolic regulation of cerebrovascular tone
Autor: | Ebbe Boedtkjer |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
medicine.medical_specialty
Intracellular pH Vasodilation 030204 cardiovascular system & hematology Acid-Base Imbalance Cerebral edema 03 medical and health sciences 0302 clinical medicine Internal medicine Extracellular medicine Animals Humans Review Articles Acid-Base Equilibrium Communication Vasomotor business.industry Blood flow Cerebral Arteries medicine.disease Respiratory acidosis Endocrinology Neurology Cerebral blood flow Cerebrovascular Circulation Neurology (clinical) Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery Signal Transduction |
Zdroj: | Boedtkjer, E 2018, ' Acid-base regulation and sensing: accelerators and brakes in metabolic regulation of cerebrovascular tone ', Journal of Cerebral Blood Flow and Metabolism, vol. 38, no. 4, pp. 588-602 . https://doi.org/10.1177/0271678X17733868 |
Popis: | Metabolic regulation of cerebrovascular tone directs blood flow to areas of increased neuronal activity and during disease states partially compensates for insufficient perfusion by enhancing blood flow in collateral blood vessels. Acid–base disturbances frequently occur as result of enhanced metabolism or insufficient blood supply, but despite definitive evidence that acid–base disturbances alter arterial tone, effects of individual acid–base equivalents and the underlying signaling mechanisms are still being debated. H+is an important intra- and extracellular messenger that modifies cerebrovascular tone. In addition, low extracellular [HCO3–] promotes cerebrovascular contraction through an endothelium-dependent mechanism. CO2alters arterial tone development via changes in intra- and extracellular pH but it is still controversial whether CO2also has direct vasomotor effects. Vasocontractile responses to low extracellular [HCO3–] and acute CO2-induced decreases in intracellular pH can counteract H+-mediated vasorelaxation during metabolic and respiratory acidosis, respectively, and may thereby reduce the risk of capillary damage and cerebral edema that could be consequences of unopposed vasodilation. In this review, the signaling mechanisms for acid–base equivalents in cerebral arteries and the mechanisms of intracellular pH control in the arterial wall are discussed in the context of metabolic regulation of cerebrovascular tone and local perfusion. |
Databáze: | OpenAIRE |
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