Vaccination against filarial worms using radiation-attenuated vaccines
| Autor: | D.A. Denham |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Filarial worms
Dirofilaria immitis Litomosoides carinii Cat Diseases Vaccines Attenuated Dogs parasitic diseases Brugia Animals Helminths Radiology Nuclear Medicine and imaging Dog Diseases Filarioidea CATS Attenuated vaccine biology Monkey Diseases Vaccination fungi Haplorhini biology.organism_classification Virology Filariasis Rats Immunization Immunology Cats Dirofilariasis |
| Zdroj: | International Journal of Nuclear Medicine and Biology. 7:105-111 |
| ISSN: | 0047-0740 |
| DOI: | 10.1016/0047-0740(80)90028-5 |
| Popis: | This review covers the published work on attempts to vaccinate animals against filarial infections. There has been consistent success when dogs were vaccinated against Dirofilaria immitis using larvae irradiated with 15–20 krad. This was shown by a greatly reduced number of adult worms, which were also stunted and few or no microfilariae. In the case of Brugia infections dogs and monkeys have been successfully protected as have cats when given a very heavy immunization schedule. Single immunizing infections with irradiated larvae were probably ineffective in cats. White rats can also be immunized against Litomosoides carinii. It is concluded that there are many difficulties to be overcome before a vaccine could be of practical use but that hope exists and more work is needed. |
| Databáze: | OpenAIRE |
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