Chemical Composition, Antioxidant, and α-Glucosidase-Inhibiting Activity of Aqueous and Hydroethanolic Extracts of Traditional Antidiabetics from Croatian Ethnomedicine
| Autor: | Ana Čačić, Isabel S. Carvalho, Andrea Brajković, Jasna Jablan, Kristina Bljajić, Marijana Zovko Končić, Lovorka Vujić |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Chromium
Polyphenol endocrine system endocrine system diseases DPPH Natural antioxidants Plant Science lcsh:Plant culture Horticulture 01 natural sciences Absinthium 03 medical and health sciences chemistry.chemical_compound food Chlorogenic acid lcsh:SB1-1110 ethnopharmacology 030304 developmental biology Flavonoids glucose-lowering activity natural antioxidants 0303 health sciences Achillea millefolium ABTS Traditional medicine biology Chemistry chromium flavonoids HPLC polyphenol Salvia officinalis nutritional and metabolic diseases biology.organism_classification food.food 0104 chemical sciences 010404 medicinal & biomolecular chemistry Ethnopharmacology Artemisia absinthium Glucose-lowering activity human activities |
| Zdroj: | Horticulturae, Vol 7, Iss 15, p 15 (2021) Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Horticulturae Volume 7 Issue 2 |
| ISSN: | 2311-7524 |
| DOI: | 10.3390/horticulturae7020015 |
| Popis: | Type 2 diabetes (T2D) is a chronic disease with a growing prevalence worldwide. In addition to the conventional therapy, many T2D patients use phytotherapeutic preparations. In the present study, chemical composition, antioxidant, and &alpha glucosidase inhibiting activity of traditional antidiabetics from Croatian ethnomedicine (Achillea millefolium, Artemisia absinthium, Centaurium erythraea, Morusalba, Phaseolus vulgaris, Sambucus nigra, and Salvia officinalis) were assessed. The efficacy of water and 80% ethanol as extraction solvents for bioactive constituents was compared. HPLC analysis revealed that the prepared extracts were rich in phenols, especially rutin, ferulic, and chlorogenic acid. Antiradical (against DPPH and ABTS radicals), reducing (towards Mo6+ and Fe3+ ions), and enzyme inhibiting properties were in linear correlation with the content of phenolic constituents. Ethanolic extracts, richer in phenolic substances, showed dominant efficacy in those assays. Aqueous extracts, on the other hand, were better Fe2+ ion chelators and more active in the &beta carotene linoleic acid assay. Extracts from S. officinalis and A. millefolium were particularly active antioxidants and &alpha glucosidase inhibitors. A. absinthium, another potent &alpha glucosidase inhibitor, contained chromium, a mineral that promotes insulin action. The investigated plants contained significant amounts of minerals useful in management of T2D, with negligible amounts of heavy metals deeming them safe for human use. |
| Databáze: | OpenAIRE |
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