Patterns of smoking and methadone dose in drug treatment patients
| Autor: | Delwyn Catley, Lisa Sanderson Cox, Kimber P. Richter, James E. Grobe, Sandra Hall, Ashley K. Hamilton |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Narcotics Methadone maintenance medicine.medical_specialty Time Factors Self Administration Drug Administration Schedule Statistics Nonparametric law.invention Drug treatment Cigarette smoking law Internal medicine medicine Humans Pharmacology (medical) Dosing Retrospective Studies Pharmacology business.industry Smoking Middle Aged Methadone dose Psychiatry and Mental health Opioid Female Smoking Cessation business Electronic cigarette Methadone medicine.drug |
| Zdroj: | Experimental and Clinical Psychopharmacology. 15:144-153 |
| ISSN: | 1936-2293 1064-1297 |
| Popis: | Cigarette smoking prevalence is very high, and cessation rates are very low, among people in methadone treatment. This may in part be due to interactions between methadone administration and cigarette smoking. The present study explores relationships between methadone dose timing and smoking rates. Twenty methadone patients, over a period of 19 days, used electronic cigarette packs to record their smoking patterns and called a voice mailbox daily to report their methadone dose and timing. The average proportion of daily cigarettes smoked was calculated for 2-hr blocks preceding and following methadone dose administration. For all participants, peak smoking rates occurred after methadone administration. Participants smoked a greater proportion of cigarettes in their first 2-hr block after methadone dosing (M = 0.368, SD = 0.135) than during their first 2-hr block of smoking of the day (M = 0.245, SD = 0.010; S = 85.5, p < .0001). The proportion of cigarettes smoked increased by 0.02 from more than 2 hr before methadone to the 2-hr time block before methadone, by 0.04 from the 2-hr time block before methadone to the 2-hr time block after methadone, and by 0.015 from the 2-hr time block after methadone to the next 2-hr time block. From this time block (2-4 hr after methadone), smoking decreased by 0.02 in the 4-plus hr postmethadone dose. All of these changes were statistically significant. Future research should use experimental designs to better examine whether a causal relationship exists and examine the impact of other types of opioid maintenance medications on smoking patterns. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|